Technology Process of ethyl 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(p-tolylsulfonyl)-1,8-naphthyridine-3-carboxylate
There total 15 articles about ethyl 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(p-tolylsulfonyl)-1,8-naphthyridine-3-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
chloroform;
for 1.5h;
Ambient temperature;
excess of reagent;
DOI:10.1002/jhet.5570240520
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 90 percent / KOH / ethanol / 2 h / Ambient temperature
2: 89 percent / KF / dimethylsulfoxide / 1 h / 130 - 135 °C
3: 84 percent / conc. H2SO4 / 1 h / 50 - 55 °C
4: 98 percent / BF3-etherate / ice-cooling, then 50-60 deg C 30 min, then reflux 23 h
5: 96 percent / NaHCO3 / dimethylformamide / 8 h / 110 - 120 °C
6: 87 percent / NaH, ethanol / toluene / 2 h / Ambient temperature
7: 83 percent / chloranil / toluene / 1.5 h / Heating
8: 89 percent / m-chloroperoxybenzoic acid / CHCl3 / 1.5 h / Ambient temperature; excess of reagent
With
potassium fluoride; potassium hydroxide; ethanol; sulfuric acid; boron trifluoride diethyl etherate; chloranil; sodium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid;
In
ethanol; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1002/jhet.5570240520
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / NaHCO3 / dimethylformamide / 8 h / 110 - 120 °C
2: 87 percent / NaH, ethanol / toluene / 2 h / Ambient temperature
3: 83 percent / chloranil / toluene / 1.5 h / Heating
4: 89 percent / m-chloroperoxybenzoic acid / CHCl3 / 1.5 h / Ambient temperature; excess of reagent
With
ethanol; chloranil; sodium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid;
In
chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1002/jhet.5570240520
