CID 9873190

Base Information

• Chemical Name: CID 9873190
• CAS No.: 88889-14-9
• Molecular Formula: C30H46NO7P . Na
• Molecular Weight: 585.65
• Hs Code.: 2933995300
• Mol file: 88889-14-9.mol

Synonyms:

Chemical Property of CID 9873190

Chemical Property:

• Appearance/Colour: white to off-white crystalline solid
• Vapor Pressure: 6.67E-21mmHg at 25°C
• Melting Point: 196-198 °C
• Boiling Point: 705.7 °C at 760 mmHg
• Flash Point: 380.6 °C
• PSA: 122.85000
• Density: 1.173
• LogP: 4.72450
• Storage Temp.: -20°C Freezer
• Solubility.: H2O: >20mg/mL
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 15
• Exact Mass: 586.29095909
• Heavy Atom Count: 40
• Complexity: 850

Purity/Quality:

99% ^*data from raw suppliers

Fosinopril-d5 Sodium Salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)OC(C(C)C)OP(=O)(CCCCC1=CC=CC=C1)CC(=O)N2CC(CC2C(=O)O)C3CCCCC3.[Na]
• Isomeric SMILES: CCC(=O)O[C@H](C(C)C)O[P@](=O)(CCCCC1=CC=CC=C1)CC(=O)N2C[C@@H](C[C@H]2C(=O)O)C3CCCCC3.[Na]
• Description: Fosinopril sodium, an ester prodrug of fosinoprilat, is the first of a new generation of phosphinic acid ACE inhibitors indicated for the once-daily treatment of hypertension. Unlike captopril and lisinopril, it is reportedly effective in increasing the left ventricular peak filling rates and peak ejection rates in hypertensive patients at rest. Another advantage is that fosinopril sodium is metabolized equally by renal and hepatic routes, thereby avoiding the requirement to modify dosage in patients with renal insufficiency.
• Uses: A phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Antihypertensive. A labelled phosphinic acid containing angiotensin converting enzyme (ACE) inhibitor. Fosinopril sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure.
• Therapeutic Function: Antihypertensive
• Clinical Use: Angiotensin-converting enzyme inhibitor: Hypertension Heart failure
• Drug interactions: Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: antagonism of hypotensive effect and increased risk of renal impairment with NSAIDs; hyperkalaemia with ketorolac and other NSAIDs. Antihypertensives: increased risk of hyperkalaemia, hypotension and renal failure with ARBs and aliskiren. Bee venom extract: possible severe anaphylactoid reactions when used together. Ciclosporin: increased risk of hyperkalaemia and nephrotoxicity. Cytotoxics: increased risk of angioedema with everolimus. Diuretics: enhanced hypotensive effect; hyperkalaemia with potassium-sparing diuretics. ESAs: increased risk of hyperkalaemia; antagonism of hypotensive effect. Gold: flushing and hypotension with sodium aurothiomalate. Lithium: reduced excretion, possibility of enhanced lithium toxicity. Potassium salts: increased risk of hyperkalaemia. Tacrolimus: increased risk of hyperkalaemia and nephrotoxicity.