Technology Process of 6-methoxy-N-methyl-5-((2-(4-(4-(pyrrolidin-1-yl)piperidin-1-yl)benzamide)pyridin-4-yl)oxy)-1H-indole-1-carboxamide
There total 12 articles about 6-methoxy-N-methyl-5-((2-(4-(4-(pyrrolidin-1-yl)piperidin-1-yl)benzamide)pyridin-4-yl)oxy)-1H-indole-1-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(4-(pyrrolidin-1-yl)piperidin-1-yl)benzoic acid;
With
oxalyl dichloride;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
5-((2-aminopyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide;
With
dmap; triethylamine;
In
dichloromethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: acetic acid; ammonium acetate / 2.33 h / 130 °C / Inert atmosphere
2.1: acetic acid; nitric acid / 3 h / 25 - 40 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / methanol; water / 3 h
4.1: potassium tert-butylate / dimethyl sulfoxide / 12.5 h / 160 °C / Inert atmosphere
5.1: methanol; sodium methylate / 5.5 h / 20 - 70 °C / Inert atmosphere
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 - 20 °C / Inert atmosphere
6.2: 3 h / 0 - 20 °C
7.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C
7.2: 20 °C
With
methanol; oxalyl dichloride; palladium 10% on activated carbon; potassium tert-butylate; ammonium acetate; hydrogen; nitric acid; sodium methylate; sodium hydride; acetic acid;
In
methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dimethyl sulfoxide / 4 h / 150 °C / Inert atmosphere; Microwave irradiation
2.1: methanol; sodium hydroxide / tetrahydrofuran / 4 h / 50 °C
3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 20 °C
3.2: 20 °C
With
methanol; oxalyl dichloride; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;