N-Methyl-N-(N,N-dimethylaminoethyl)-aminoethanol

Base Information

• Chemical Name: N-Methyl-N-(N,N-dimethylaminoethyl)-aminoethanol
• CAS No.: 2212-32-0
• Deprecated CAS: 163759-39-5,205132-49-6
• Molecular Formula: C7H18N2O
• Molecular Weight: 146.233
• Hs Code.: 2922199090
• European Community (EC) Number: 218-658-4
• UNII: T6E4BJ0CD0
• DSSTox Substance ID: DTXSID9044875
• Nikkaji Number: J39.352E
• Wikidata: Q27289735
• ChEMBL ID: CHEMBL3183684
• Mol file: 2212-32-0.mol

Synonyms:Toyocat RX 5;N-(Dimethylaminoethyl)-N-methylethanolamine;N-(2-Dimethylaminoethyl)-N-methylethanolamine;N,N,N'-Trimethylaminoethylethanolamine;N,N,N'-Trimethyl-N'-(hydroxyethyl)ethylenediamine;N,N,N'-Trimethyl-N'-(2-hydroxyethyl)ethylenediamine;Kaolizer 28;Jeffcat Z 110;Dabco T;2-[[2-(Dimethylamino)ethyl]methylamino]ethanol;

Chemical Property of N-Methyl-N-(N,N-dimethylaminoethyl)-aminoethanol

Chemical Property:

• Vapor Pressure: 0.0541mmHg at 25°C
• Refractive Index: n20/D 1.4539(lit.)
• Boiling Point: 206.999 °C at 760 mmHg
• PKA: 14.72±0.10(Predicted)
• Flash Point: 66 °C
• PSA: 26.71000
• Density: 0.937 g/cm³
• LogP: -0.52790
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Methanol (Slightly)
• Water Solubility.: 1000g/L at 20℃
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 146.141913202
• Heavy Atom Count: 10
• Complexity: 76

Purity/Quality:

99% ^*data from raw suppliers

2-{[2-(Dimethylamino)ethyl]methylamino}ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCN(C)CCO
• Uses: 2-{[2-(Dimethylamino)ethyl]methylamino}ethanol (dmemH) has been used in the preparation of new iron clusters:[Fe7O4(O2CPh)11(dmem)2][Fe7O4 (O2CMe)11(dmem)2][Fe6O2(OH)4(O2CBut)8(dmem)2]

Technology Process of N-Methyl-N-(N,N-dimethylaminoethyl)-aminoethanol

There total 4 articles about N-Methyl-N-(N,N-dimethylaminoethyl)-aminoethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(2-Aminoethylamino)ethanol (111-41-1) → 2-{[2-(dimethylamino)ethyl]methylamino}ethanol (2212-32-0)

Guidance literature:

formaldehyd; 2-(2-Aminoethylamino)ethanol; at 80 - 90 ℃; for 0.5h;

With formic acid; at 80 - 90 ℃; for 2h;

In butan-1-ol; at 120 ℃; for 4h; Temperature; Solvent;

Reference yield: 27.3%

→ N1-[3-[2-(1H-indol-5-yl)-5-[[(4S)-4-methyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl)carbonyl] phenoxy]propyl]-N1,N2,N2-trimethyl-1,2-ethaneamine + 2-{[2-(dimethylamino)ethyl]methylamino}ethanol (2212-32-0)

Guidance literature:

Reference yield:

(2-hydroxyethyl)(methyl)amine (109-83-1) + 2-(dimethylamino)ethyl chloride (107-99-3) → 2-{[2-(dimethylamino)ethyl]methylamino}ethanol (2212-32-0)

Guidance literature:

With potassium carbonate; In ethanol; Heating;

upstream raw materials:

formaldehyd

2-(2-Aminoethylamino)ethanol

(2-hydroxyethyl)(methyl)amine

2-(dimethylamino)ethyl chloride

Downstream raw materials:

N,N,N'-Trimethyl-N'-[2-(phenyl-o-tolyl-methoxy)-ethyl]-ethane-1,2-diamine

N-(2-Benzhydryloxy-ethyl)-N,N',N'-trimethyl-ethane-1,2-diamine

N-{2-[Bis-(2,6-dimethyl-phenyl)-methoxy]-ethyl}-N,N',N'-trimethyl-ethane-1,2-diamine

C₁₆H₂₇N₃O₂

Refernces

• 1、 -. "Synthesizing method for N,N,N'-trimethyl-N'-ethoxyl-ethidene diamine". Paragraph 0026; 0032-0038. . Retrieved 2017/04/03.
• 2、 -. "2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION". . . Retrieved 2008/06/13.