Technology Process of tert-butyl [6-(bromomethyl)pyridin-2-yl](2-cyclohexylethyl)carbamate
There total 6 articles about tert-butyl [6-(bromomethyl)pyridin-2-yl](2-cyclohexylethyl)carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl (2-cyclohexylethyl)[6-(hydroxymethyl)pyridin-2-yl]carbamate;
With
pyridine; sulfurous dibromide;
In
dichloromethane;
at 0 - 20 ℃;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / dmap / dichloromethane / 5 h / 0 °C
2.1: n-butyllithium; methyllithium / tetrahydrofuran
2.2: 1.5 h / -78 - 20 °C
3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C
4.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.08 h / 0 °C
4.2: 4 h / 20 °C
5.1: pyridine; sulfurous dibromide / dichloromethane / 0 - 20 °C
5.2: Cooling with ice
With
pyridine; sodium tetrahydroborate; sulfurous dibromide; n-butyllithium; potassium tert-butylate; methyllithium; triethylamine;
dmap;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.08 h / 0 °C
1.2: 4 h / 20 °C
2.1: pyridine; sulfurous dibromide / dichloromethane / 0 - 20 °C
2.2: Cooling with ice
With
pyridine; sulfurous dibromide; potassium tert-butylate;
In
dichloromethane; N,N-dimethyl-formamide;