2-Chloro-3-methoxy-5-nitropyridine

Base Information

• Chemical Name: 2-Chloro-3-methoxy-5-nitropyridine
• CAS No.: 75711-00-1
• Molecular Formula: C6H5ClN2O3
• Molecular Weight: 188.57
• Hs Code.: 2933399090
• Mol file: 75711-00-1.mol

Synonyms:2-Chloro-3-(methyloxy)-5-nitropyridine;2-Chloro-3-methoxy-5-nitropyridine;

Chemical Property of 2-Chloro-3-methoxy-5-nitropyridine

Chemical Property:

• Vapor Pressure: 0.00116mmHg at 25°C
• Refractive Index: 1.564
• Boiling Point: 309.6 °C at 760 mmHg
• PKA: -5.07±0.10(Predicted)
• Flash Point: 141 °C
• PSA: 67.94000
• Density: 1.445 g/cm³
• LogP: 2.17500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-3-methoxy-5-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloro-3-methoxy-5-nitro-pyridine

Technology Process of 2-Chloro-3-methoxy-5-nitropyridine

There total 3 articles about 2-Chloro-3-methoxy-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-methoxy-5-nitropyridin-2-ol (75710-99-5) → 2-chloro-3-methoxy-5-nitropyridine (75711-00-1)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; for 4h; Reflux;

Reference yield:

3-methoxy-2-hydroxypyridine (20928-63-6,95907-05-4) → 2-chloro-3-methoxy-5-nitropyridine (75711-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid / 3 h / 0 - 40 °C

2: trichlorophosphate; phosphorus pentachloride / 4 h / Reflux

With phosphorus pentachloride; sulfuric acid; nitric acid; trichlorophosphate;

Reference yield:

dihydroxypyridine (16867-04-2) → 2-chloro-3-methoxy-5-nitropyridine (75711-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 20 h / 5 - 20 °C

1.2: 0.5 h / 5 - 15 °C

2.1: phosphorus pentachloride; trichlorophosphate / 2.5 h / 100 °C / Heating / reflux

With sodium hydroxide; phosphorus pentachloride; trichlorophosphate; In water;

upstream raw materials:

3-methoxy-5-nitropyridin-2-ol

3-methoxy-2-hydroxypyridine

dihydroxypyridine

Downstream raw materials:

phenyl 5-methoxy-6-(pyrrolidin-1-yl)pyridin-3-ylcarbamate

1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(5-methoxy-6-(pyrrolidin-1-yl)pyridin-3-yl)urea

2,3-dimethoxy-5-nitropyridine

ethyl 3-methoxy-5-aminopyridine-2-carboxylate

Refernces

• 1、 -. "Substituted Heteroaromatic Pyrazole-Containing Carboxamide and Urea Compounds as Vanilloid Receptor Ligands". Paragraph 0983. . Retrieved 2013/03/26.
• 2、 -. "AZAINDOLE DERIVATIVES AS INHIBITORS OF P38 KINASE". Page/Page column 91. . Retrieved 2010/11/24.