C₁₅H₁₉⁽²⁾HO₂

Base Information

• Chemical Name: C₁₅H₁₉⁽²⁾HO₂
• CAS No.: 1033424-99-5
• Molecular Formula: C₁₅H₂₀O₂
• Molecular Weight: 233.315
• Mol file: 1033424-99-5.mol

Synonyms:C₁₅H₁₉⁽²⁾HO₂

Chemical Property of C₁₅H₁₉⁽²⁾HO₂

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₁₅H₁₉⁽²⁾HO₂

There total 3 articles about C₁₅H₁₉⁽²⁾HO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 2-octynoate (111-12-6,53073-28-2) + phenylboronic acid-d2 (20469-72-1) → C15H19(2)HO2 (1033424-99-5)

Guidance literature:

With cobalt acetylacetonate; 1,2-bis-(diphenylphosphino)ethane; In tetrahydrofuran; acetonitrile; at 80 ℃; for 12h; stereoselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1002/chem.200801858

Reference yield: 78.0%

methyl 2-octynoate (111-12-6,53073-28-2) + 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane (5123-13-7) → C15H19(2)HO2 (1033424-99-5)

Guidance literature:

With deuteromethanol; copper (I) acetate; at 28 ℃; for 24h; stereoselective reaction; Inert atmosphere;

DOI:10.1039/b802231c

Reference yield:

methyl 2-octynoate (111-12-6,53073-28-2) + phenylboronic acid (98-80-6) → C15H19(2)HO2 (1033424-99-5) + methyl (E)-3-phenyl-2-octenoate (189890-29-7)

Guidance literature:

With deuteromethanol; copper (I) acetate; at 28 ℃; for 24h; stereoselective reaction; Inert atmosphere;

DOI:10.1039/b802231c

upstream raw materials:

methyl 2-octynoate

5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane

phenylboronic acid

phenylboronic acid-d₂

Refernces

• 1、 Lin, Pao-Shun,Jeganmohan, Masilamani,Cheng, Chien-Hong. "Cobalt(II)-catalyzed regio- And stereoselective hydroarylation of alkynes with organoboronic acids". supporting information; experimental part. p. 11296 - 11299. Retrieved 2009/12/05.