3,5-Dimethoxybenzylamine

Base Information

• Chemical Name: 3,5-Dimethoxybenzylamine
• CAS No.: 34967-24-3
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.208
• Hs Code.: 29222990
• Mol file: 34967-24-3.mol

Synonyms:Benzylamine,3,5-dimethoxy- (6CI);(3,5-Dimethoxyphenyl)methanamine;1-Aminomethyl-3,5-dimethoxybenzene;3,5-Bis(methyloxy)benzylamine;3,5-Dimethoxybenzenemethanamine;3,5-Dimethoxybenzylamine;[(3,5-Dimethoxyphenyl)methyl]amine;

Chemical Property of 3,5-Dimethoxybenzylamine

Chemical Property:

• Appearance/Colour: Colorless to light yellow liquid
• Vapor Pressure: 0.000226mmHg at 25°C
• Melting Point: 35-37 °C(lit.)
• Refractive Index: n20/D 1.542(lit.)
• Boiling Point: 325.7 °C at 760 mmHg
• PKA: 9.01±0.10(Predicted)
• Flash Point: 135.8 °C
• PSA: 44.48000
• Density: 1.062 g/cm³
• LogP: 1.86280
• Storage Temp.: 0-10°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

3,5-Dimethoxybenzylamine >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,5-Dimethoxybenzylamine was used in the preparation of trisammonium tris(hexafluoro phosphate) salt. ?It was also used in the synthesis of well defined, homogeneous [n]rotaxanes (n?up to 11) by a template-directed thermodynamic clipping approach. 3,5-Dimethoxybenzylamine was used in the preparation of trisammonium tris(hexafluoro phosphate) salt. It was also used in the synthesis of well defined, homogeneous [n]rotaxanes (n up to 11) by a template-directed thermodynamic clipping approach.

Technology Process of 3,5-Dimethoxybenzylamine

There total 11 articles about 3,5-Dimethoxybenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ 3,5-dimethoxybenzylamine (34967-24-3)

Guidance literature:

With ammonia; hydrogen; In methanol; at 90 ℃; for 4h; under 15001.5 Torr; Autoclave;

Reference yield: 22.8%

C17H17NO5 → 3,5-dimethoxybenzylamine (34967-24-3)

Guidance literature:

With ethylenediamine; In 1,4-dioxane; propan-1-ol; water; for 24h; Reflux;

DOI:10.1021/ol301037s

Reference yield:

3,5-dimethoxybenzaldehdye (7311-34-4) → 3,5-dimethoxybenzylamine (34967-24-3)

Guidance literature:

3,5-dimethoxybenzaldehdye; With Rink resin; trimethyl orthoformate; at 25 ℃; for 2h;

With lithium borohydride; In tetrahydrofuran; at 65 ℃; for 5h;

With trifluoroacetic acid; In dichloromethane; at 25 ℃;

DOI:10.1021/jm051076e

upstream raw materials:

3,5-dimethoxybenzamide

3,5-dimethoxy-benzonitrile

3-carbamoyl-1,5-dimethoxy-1,4-cyclohexanediene

3,5-dimethoxybenzaldoxime

Downstream raw materials:

4-benzylsulfanyl-2-[[(3,5-dimethoxy-benzylcarbamoyl)-methyl]-(4-methoxy-benzenesulfonyl)-amino]-butyric acid methyl ester

(2-chloro-pyrido[2,3-d]pyrimidin-4-yl)-(3,5-dimethoxy-benzyl)-amine

C₂₅H₃₁N₃O₅

tert-butyl (2S,3R)-1-cyclohexyl-4-(3,5-dimethoxybenzylamino)-3-hydroxybutan-2-ylcarbamate

Refernces

• 1、 -. "Method for preparing primary amine by catalyzing reductive amination of aldehyde ketone compounds". Paragraph 0027-0030; 0051-0055. . Retrieved 2020/05/30.
• 2、 Liu, Lei,Li, Jifan,Ai, Yongjian,Liu, Yuhong,Xiong, Jialiang,Wang, Hongdong,Qiao, Yijun,Liu, Wenrui,Tan, Shanchao,Feng, Shaofei,Wang, Kunpeng,Sun, Hongbin,Liang, Qionglin. "A ppm level Rh-based composite as an ecofriendly catalyst for transfer hydrogenation of nitriles: Triple guarantee of selectivity for primary amines". . p. 1390 - 1395. Retrieved 2019/03/26.