3-Bromobenzylamine

Base Information

• Chemical Name: 3-Bromobenzylamine
• CAS No.: 10269-01-9
• Molecular Formula: C7H8BrN
• Molecular Weight: 186.051
• Hs Code.: 29214900
• Mol file: 10269-01-9.mol

Synonyms:Benzylamine,m-bromo- (7CI,8CI);(3-Bromophenyl)methanamine;3-(Aminomethyl)bromobenzene;3-Aminomethyl-1-bromobenzene;m-Bromobenzenemethanamine;m-Bromobenzylamine;

Chemical Property of 3-Bromobenzylamine

Chemical Property:

• Appearance/Colour: clear yellow liquid
• Vapor Pressure: 0.0303mmHg at 25°C
• Refractive Index: 1.584-1.586
• Boiling Point: 244.499 °C at 760 mmHg
• PKA: 8.77±0.10(Predicted)
• Flash Point: 104.347 °C
• PSA: 26.02000
• Density: 1.481 g/cm³
• LogP: 2.60810
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromobenzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-21/22
• Safety Statements: 45-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromobenzylamine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agro chemicals, dyestuff.

Technology Process of 3-Bromobenzylamine

There total 23 articles about 3-Bromobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-cyanobromobenzene (6952-59-6) → 3-bromobenzylamine (10269-01-9)

Guidance literature:

With Zr₁₂(μ₃-O)₅[(μ₃-O)CoCl]₈[(μ₂-O)₂(μ₃-O)CoCl]₃Li₃(triphenyldicarboxylate)₉; hydrogen; In toluene; at 110 ℃; for 42h; under 30003 Torr; Catalytic behavior; Inert atmosphere; Schlenk technique;

DOI:10.1021/jacs.7b02394

Reference yield: 98.2%

m-bromobenzoic aldehyde (3132-99-8) → 3-bromobenzylamine (10269-01-9)

Guidance literature:

With ammonium hydroxide; hydrogen; In methanol; water; at 30 ℃; for 4h; under 1520.1 Torr; Reagent/catalyst;

Reference yield: 95.0%

3-bromobenzaldehyde oxime (51873-95-1,52739-46-5,32605-62-2) → 3-bromobenzylamine (10269-01-9)

Guidance literature:

With sodium hydrogensulfate monohydrate; molybdenum(V) chloride; sodium cyanoborohydride; In ethanol; for 0.8h; Reflux;

DOI:10.5012/bkcs.2011.32.9.3323

upstream raw materials:

3-bromobenzamide

2-(3-bromobenzyl)isoindoline-1,3-dione

3-cyanobromobenzene

3-bromobenzaldehyde oxime

Downstream raw materials:

3-(3-bromo-benzyl)-5-(2-hydroxy-ethyl)-[1,3,5]thiadiazinane-2-thione

(3-bromo-benzyl)-urea

2-amino-4,6-dichloro-N-(3-bromo-benzyl)-benzamide

C₁₄H₁₁Br₂NO₂

Refernces

• 1、 Zeynizadeh, Behzad,Zahmatkesh, Karam. "First report for the efficient reduction of oximes to amines with zinc borohydride in the form of (Pyridine)(tetrahydroborato)zinc complex". . p. 109 - 112. Retrieved 2005.
• 2、 Bhanage, Bhalchandra M.,Gokhale, Tejas A.,Raut, Amol B.. "Comparative account of catalytic activity of Ru- and Ni-based nanocomposites towards reductive amination of biomass derived molecules". . . Retrieved 2021/06/18.
• 3、 -. "Preparation method of (1R)-5-bromo-2,3-dihydro-1-methyl-1H-isoindole". Paragraph 0044; 0050-0051; 0054-0055; 0058-0059; 0062-0063. . Retrieved 2020/04/17.