Benzhydrylamine hydrochloride

Base Information

• Chemical Name: Benzhydrylamine hydrochloride
• CAS No.: 5267-34-5
• Molecular Formula: C13H13N^.HCl
• Molecular Weight: 219.714
• Hs Code.: 29214990
• European Community (EC) Number: 226-084-0
• NSC Number: 18792
• UNII: LZ568SDT78
• DSSTox Substance ID: DTXSID00200644
• Mol file: 5267-34-5.mol

Synonyms:Benzhydrylamine hydrochloride;5267-34-5;Aminodiphenylmethane hydrochloride;diphenylmethanamine hydrochloride;Benzhydrylammonium chloride;diphenylmethanamine;hydrochloride;1,1-Diphenylmethylamine hydrochloride;EINECS 226-084-0;MFCD00013023;NSC-18792;MFCD00801155;Benzenemethanamine, alpha-phenyl-, hydrochloride;Benzhydrylaminehydrochloride;Benzhydrylamine HCl;C13H13N.ClH;diphenylmethylamine hydrochloride;LZ568SDT78;SCHEMBL1764753;Biphenylmethylamine hydrochloride;DTXSID00200644;BCP18639;NSC18792;NSC 18792;AKOS015905734;alpha-Aminodiphenylmethane Hydrochloride;Methylamine,1-diphenyl-, hydrochloride;SB79384;Aminodiphenylmethane hydrochloride, 97%;BP-12847;DS-10699;SY057105;Methylamine, 1,1-diphenyl-, hydrochloride;Benzenemethanamine, -phenyl-, hydrochloride;A0839;CS-0022274;FT-0622664;EN300-30060;D78195;A829195;Benzenemethanamine, .alpha.-phenyl-, hydrochloride;Z56753978;Benzenemethanamine, alpha-phenyl-, hydrochloride (1:1);Benzhydrylamine Resin (1% DVB, 100-200 mesh, 0.1-0.4 mmol/g);Benzhydrylamine Resin (1% DVB, 100-200 mesh, 0.5-1.5 mmol/g);Benzhydrylamine Resin (1% DVB, 100-200 mesh, 1.6-2.5 mmol/g);Benzhydrylamine Resin (1% DVB, 200-400 mesh, 0.1-0.4 mmol/g);Benzhydrylamine Resin (1% DVB, 200-400 mesh, 0.5-1.5 mmol/g)

Chemical Property of Benzhydrylamine hydrochloride

Chemical Property:

• Appearance/Colour: white to off-white crystalline powder
• Vapor Pressure: 0.00108mmHg at 25°C
• Melting Point: 293-295 °C(lit.)
• Boiling Point: 301.1 °C at 760 mmHg
• Flash Point: 141.8 °C
• PSA: 26.02000
• Density: 1.057 g/cm³
• LogP: 4.23700
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 219.0814771
• Heavy Atom Count: 15
• Complexity: 137

Purity/Quality:

99% ^*data from raw suppliers

Benzhydrylamine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)N.Cl
• Uses: Benzhydrylamine Hydrochloride is used as molecular tools to block maturation of nuclear lamin A and decelerate cancer cell migration.

Technology Process of Benzhydrylamine hydrochloride

There total 12 articles about Benzhydrylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

benzophenone N-benzhydrylimine (5350-59-4) → aminodiphenylmethane hydrochloride (5267-34-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c3sc53526f

Reference yield: 80.3%

N-benzhydrylformamide (6744-65-6) → aminodiphenylmethane hydrochloride (5267-34-5)

Guidance literature:

With hydrogenchloride; pyrographite; In ethanol; water; for 1.5h; Reflux;

Reference yield: 46.0%

Diphenylmethane (101-81-5) → aminodiphenylmethane hydrochloride (5267-34-5)

Guidance literature:

Diphenylmethane; With Benzophenone imine; copper(l) iodide; 1,10-Phenanthroline; di-tert-butyl peroxide; In chlorobenzene; at 90 ℃; for 48h; Inert atmosphere; Sealed tube;

With hydrogenchloride; In methanol; water; chlorobenzene; at 40 ℃; for 15h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.8b03505

upstream raw materials:

1-<(diphenylmethylene)amino>-3-phenyl-4-methyl-5-methoxypyrazole

benzophenone

Benzhydrylamine

Benzophenone oxime

Downstream raw materials:

Carbobenzoxy-L-leucin-diphenylmethylamid

Carbobenzoxy-L-glutaminsaeure-γ-diphenylmethylamid

[1-(Benzhydryl-amino)-2-benzyloxy-propyl]-phosphinic acid

[1-(Benzhydryl-amino)-2-benzylsulfanyl-ethyl]-phosphinic acid

Refernces

• 1、 Sun, Quan-Wei,Xing, Jun-De,Qin, Yu-Hong,Yin, Xu-Wen,Zhou, Yi. "Benzhydrylamine: An effective aminating agent for the synthesis of primary amines". . p. 181 - 183. Retrieved 2018/05/26.
• 2、 -. "APPLICATIONS OF N6-SUBSTITUTED ADENOSINE DERIVATIVE AND N6-SUBSTITUTED ADENINE DERIVATIVE TO CALMING, HYPNOSES, CONVULSION RESISTANCE, EPILEPTIC RESISTANCE, PARKINSON DISEASE RESISTANCE, AND DEMENTIA PREVENTION AND TREATMENT". Paragraph 0187. . Retrieved 2018/10/27.