Trimethylchlorosilane

Base Information Edit

Chemical Name:Trimethylchlorosilane
CAS No.:75-77-4
Deprecated CAS:127290-36-2,36642-33-8
Molecular Formula:C3H9ClSi
Molecular Weight:108.643
Hs Code.:29310095
European Community (EC) Number:200-900-5
ICSC Number:0966
NSC Number:15750
UN Number:1298
UNII:62UO4690X6
DSSTox Substance ID:DTXSID2024822
Nikkaji Number:J1.466D
Wikipedia:Trimethylsilyl_chloride
Wikidata:Q420183
ChEMBL ID:CHEMBL1505385
Mol file:75-77-4.mol

Synonyms:chlorotrimethylsilane;trimethylchlorosilane

Suppliers and Price of Trimethylchlorosilane

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Chlorotrimethylsilane
100g
$ 155.00

TCI Chemical
Chlorotrimethylsilane >98.0%(GC)
100mL
$ 19.00

TCI Chemical
Chlorotrimethylsilane >98.0%(GC)
25mL
$ 16.00

TCI Chemical
Chlorotrimethylsilane >98.0%(GC)
500mL
$ 43.00

SynQuest Laboratories
Trimethylchlorosilane 99%
1 L
$ 64.00

SynQuest Laboratories
Trimethylchlorosilane 99%
250 mL
$ 24.00

Strem Chemicals
Trimethylchlorosilane, min. 97%
500g
$ 131.00

Strem Chemicals
Trimethylchlorosilane, min. 97%
100g
$ 40.00

Soltec Ventures
Trichloromethylsilane,99+% 99+%
10
$ 5.04

Sigma-Aldrich
Chlorotrimethylsilane produced by Wacker Chemie AG, Burghausen, Germany, ≥99.0% (GC)
25kg-f
$ 1270.00

Total 158 raw suppliers

Chemical Property of Trimethylchlorosilane Edit

Chemical Property:

Appearance/Colour:colourless liquid
Vapor Pressure:100 mm Hg ( 25 °C)
Melting Point:-40 °C(lit.)
Refractive Index:n20/D 1.500
Boiling Point:58.737 °C at 760 mmHg
Flash Point:-18 °C
PSA：0.00000
Density:0.868 g/cm³
LogP:2.06010
Storage Temp.:Store at RT.
Sensitive.:Moisture Sensitive
Solubility.:Miscible with ether, benzene, diethylether and perchloroethylene
Water Solubility.:REACTS
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:0
Rotatable Bond Count:0
Exact Mass:108.0162045
Heavy Atom Count:5
Complexity:28.4
Transport DOT Label:Flammable Liquid Corrosive

Purity/Quality:

98% ^*data from raw suppliers

Chlorotrimethylsilane ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,C
Hazard Codes:T,F,C,Xn
Statements: 20/21-36/38-34-21-14-11-37-35-19-40-10-67-20/21/22-52
Safety Statements: 26-36/37/39-45-16-36/37-7/9

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Toxic Gases & Vapors -> Chlorosilanes
Canonical SMILES:C[Si](C)(C)Cl
Inhalation Risk:No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.
Effects of Short Term Exposure:The substance and the vapour are corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. Exposure could cause death. Medical observation is indicated.
Description Chlorotrimethylsilane is a valuable reagent for the protection of the hydroxyl function in organic synthesis. It should be distilled from calciumhydride (or tributylamine) under nitrogen before use,and stored and weighed under nitrogen. Use of the reagent without purification has been reported to lead to explosions. Chlorotrimethylsilane may contain dichlorodimethylsilane as an impurity. This may be removed before distillation by very cautious treatment with a small amount of water，which hydrolyses the dichloro compound more rapidly. Excess chlorotrimethylsilane in a reaction mixture may be destroyed by the very careful addition of aqueous sodium hydrogencarbonate solution.
Uses Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis. It is used in the production of trimethylsilyl halides, pseudohalides and various organic silicon compounds. It is also used to produce hexamethyldisilane by reduction.

Technology Process of Trimethylchlorosilane

There total 957 articles about Trimethylchlorosilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: bis[bis(trimethylsilyl)amido][[(trimethylsilyl)methyl]stannyl]praseodymium*0.5(dimethoxyethane)

: 75-77-4
chloro-trimethyl-silane

: 1333-74-0
hydrogen

: 10361-79-2
praseodymium(III) chloride

: 34570-67-7
Chlor-tris<(trimethylsilyl)methyl>zinn

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; mixt. od dry HCl (excess), Pr/Sn-complex and THF keeping dor 1 d at room temp., THF replacing by hexane in usual way; ppt. filtration of, hexane-soln. evapn. (vac.), residue crystn. twice (hexane, -70°C), GLC of volatiles;