2-Amino-6-methoxy-3-nitropyridine

Base Information

• Chemical Name: 2-Amino-6-methoxy-3-nitropyridine
• CAS No.: 73896-36-3
• Molecular Formula: C6H7N3O3
• Molecular Weight: 169.14
• Hs Code.: 29333990
• DSSTox Substance ID: DTXSID50397331
• Nikkaji Number: J985.074K
• Wikidata: Q72438782
• Mol file: 73896-36-3.mol

Synonyms:2-Amino-6-methoxy-3-nitropyridine;73896-36-3;6-methoxy-3-nitropyridin-2-amine;2-Amino-3-nitro-6-methoxypyridine;2-PYRIDINAMINE, 6-METHOXY-3-NITRO-;MFCD03206481;2-AMINO-3-NITRO-6-METHOXY PYRIDINE;6-Methoxy-3-nitro-2-pyridinamine;SCHEMBL336303;DTXSID50397331;2-amino-6methoxy-3-nitropyridine;RDJILYVRVOTMTQ-UHFFFAOYSA-N;6-Methoxy-3-nitro-2-pyridineamine;2-amino-6-methoxy-3-nitro pyridine;STK785094;AKOS005254874;6-(Methyloxy)-3-nitro-2-pyridinamine;AB13809;AC-3112;CS-W003032;DS-0598;PS-5504;SY003853;2-Amino-6-methoxy-3-nitropyridine, 97%;6-METHOXY-3-NITRO-PYRIDIN-2-YLAMINE;A9509;AM20061475;FT-0641493;EN300-127483;J-400238;Z1255419867

Chemical Property of 2-Amino-6-methoxy-3-nitropyridine

Chemical Property:

• Appearance/Colour: yellow crystalline powder
• Vapor Pressure: 9.75E-05mmHg at 25°C
• Melting Point: 171-172 °C
• Refractive Index: 1.608
• Boiling Point: 338.5 °C at 760 mmHg
• PKA: 0.17±0.50(Predicted)
• Flash Point: 158.5 °C
• PSA: 93.96000
• Density: 1.4 g/cm³
• LogP: 1.68500
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 169.04874109
• Heavy Atom Count: 12
• Complexity: 170

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-6-methoxy-3-nitropyridine >97.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC(=C(C=C1)[N+](=O)[O-])N

Technology Process of 2-Amino-6-methoxy-3-nitropyridine

There total 13 articles about 2-Amino-6-methoxy-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-amino-6-methoxypyridine (17920-35-3) → 6-methoxy-3-nitropyridin-2-amine (73896-36-3)

Guidance literature:

With sulfuric acid; potassium nitrate; at 75 ℃; for 2h;

Reference yield: 87.0%

O-Methylhydroxylamin (67-62-9) + 2-methoxy-5-nitropyridine (5446-92-4) + zinc(II) chloride (7646-85-7,24359-56-6) → 6-methoxy-3-nitropyridin-2-amine (73896-36-3)

Guidance literature:

With ammonium chloride; potassium tert-butylate; In dimethyl sulfoxide;

Reference yield: 87.0%

2-methoxy-5-nitropyridine (5446-92-4) → 6-methoxy-3-nitropyridin-2-amine (73896-36-3)

Guidance literature:

With O-Methylhydroxylamin; potassium tert-butylate; zinc(II) chloride; In dimethyl sulfoxide; Ambient temperature;

DOI:10.1039/a803497d

upstream raw materials:

2-amino-6-methoxypyridine

2-methoxy-5-nitropyridine

methanol

2-amino-6-chloro-3-nitropyridine

Downstream raw materials:

5-iodo-6-methoxy-3-nitropyridin-2-amine

6-methoxy-3-nitro-2-(1-pyrrolyl)pyridine

6-methoxypyridine-2,3-diamine dihydrochloride

Refernces

• 1、 Xie, Dongsheng,Lu, Jun,Xie, Jin,Cui, Junjun,Li, Teng-Fei,Wang, Yan-Chao,Chen, Yuan,Gong, Nian,Li, Xin-Yan,Fu, Lei,Wang, Yong-Xiang. "Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3- b ]pyrazine-2,3-dione as a novel potent d -amino acid oxidase inhibitor". . p. 19 - 32. Retrieved 2016/05/11.
• 2、 Sharada,Satyanarayana Reddy,Sammaiah,Sumalatha. "Diversified synthesis of novel quinoline and dibenzo thiazepine derivatives using known active intermediates". . p. 7959 - 7966. Retrieved 2013/09/23.