3-(2-hydroxyphenyl)cyclobutanone

Base Information

• Chemical Name: 3-(2-hydroxyphenyl)cyclobutanone
• CAS No.: 294669-29-7
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.188
• Mol file: 294669-29-7.mol

Synonyms:3-(2-hydroxyphenyl)cyclobutanone

Chemical Property of 3-(2-hydroxyphenyl)cyclobutanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-hydroxyphenyl)cyclobutanone

There total 1 articles about 3-(2-hydroxyphenyl)cyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H16O2 → 3-(2-hydroxyphenyl)cyclobutanone (294669-29-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; at 20 ℃;

DOI:10.1021/ja075141g

Reference yield: 83.0%

1-bromo-4-methoxy-benzene (104-92-7) + 3-(2-hydroxyphenyl)cyclobutanone (294669-29-7) → 4-(4-methoxylbenzyl)-3,4-dihydrocoumarin (1080564-05-1)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In toluene; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol802218a

Reference yield: 79.0%

4-iodobenzoic acid ethyl ester (51934-41-9) + 2-(2-hydroxyphenyl)cyclobutanone (294669-29-7) → 5-[4-(ethoxycarbonyl)phenyl]-4,5-dihydrobenzo[b]oxepin-2(3H)-one (1080564-09-5)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In toluene; at 40 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol802218a

Downstream raw materials:

4-methyl-2H-chromen-2-one

4-methyl-chroman-2-one

benzo[b]oxepin-2(5H)-one

4,5-dihydro-3H-benzo[b]oxepin-2-one

Refernces