1-Bromo-4-methoxybutane

Base Information

• Chemical Name: 1-Bromo-4-methoxybutane
• CAS No.: 4457-67-4
• Molecular Formula: C5H11 Br O
• Molecular Weight: 167.046
• Hs Code.: 2909199090
• Mol file: 4457-67-4.mol

Synonyms:Ether,4-bromobutyl methyl (6CI,7CI,8CI);1-Bromo-4-methoxybutane;1-Methoxy-4-bromobutane;4-Bromobutyl methyl ether;4-Methoxybutyl bromide;Methyl 4-bromobutyl ether;w-Bromobutyl methyl ether;

Chemical Property of 1-Bromo-4-methoxybutane

Chemical Property:

• Vapor Pressure: 3.33mmHg at 25°C
• Refractive Index: 1.443
• Boiling Point: 158.9 ºC at 760 mmHg
• Flash Point: 59.6 ºC
• PSA: 9.23000
• Density: 1.278
• LogP: 1.80790
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Bromo-4-methoxybutane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Bromo-4-methoxybutane

There total 7 articles about 1-Bromo-4-methoxybutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methanol (67-56-1) + bromobutyric acid (2623-87-2) → 4-Methoxy-1-bromobutane (4457-67-4) + 4-Bromo-1-butanol (33036-62-3)

Guidance literature:

bromobutyric acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

methanol; With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1055/s-0030-1259988

Reference yield: 48.5%

1,4-dibromo-butane (110-52-1) + sodium methylate (124-41-4) → 4-Methoxy-1-bromobutane (4457-67-4)

Guidance literature:

In methanol; 1.) room temp., overnight, 2.) reflux, 1 h;

DOI:10.1248/cpb.28.1422

Reference yield: 32.0%

4-methoxybutanol (111-32-0) → 4-Methoxy-1-bromobutane (4457-67-4)

Guidance literature:

In water;

upstream raw materials:

1,4-dibromo-butane

sodium methylate

methanol

4-methoxybutanol

Downstream raw materials:

tetrahydrofuran

N-(4-Methoxy-butyl)-N-phenyl-hydrazine

(3R,4R,5S)-3-hydroxy-4-[4-(4-methoxy-butoxy)-phenyl]-5-triisopropylsilanyloxy-piperidine-1-carboxylic acid benzyl ester

1‐(3,4‐dichlorophenyl)‐5‐methoxypentan‐1‐one

Refernces

• 1、 Morales-Serna, Jose Antonio,Garcia-Rios, Erendira,Bernal, Jorge,Paleo, Ehecatl,Gavino, Ruben,Cardenas, Jorge. "Reduction of carboxylic acids using esters of benzotriazole as high-reactivity intermediates". scheme or table. p. 1375 - 1382. Retrieved 2011/06/19.
• 2、 Gustavsson, Anna-Lena,Liljefors, Tommy,Hansson, Bill S.. "Alkyl Ether and Enol Ether Analogs of (Z)-5-Decenyl Acetate, a Pheromone Component of the Turnip Moth, Agrotis segetum: Probing a Proposed Bioactive Conformation for Chain-Elongated Analogs". . p. 815 - 832. Retrieved 2007/10/03.