Salicyl alcohol

Base Information

• Chemical Name: Salicyl alcohol
• CAS No.: 90-01-7
• Molecular Formula: C7H8O2
• Molecular Weight: 124.139
• Hs Code.: 29072900
• European Community (EC) Number: 201-960-5
• NSC Number: 757317,3814
• UNII: FA1N0842KB
• DSSTox Substance ID: DTXSID9045843
• Nikkaji Number: J4.312E
• Wikipedia: Salicyl_alcohol
• Wikidata: Q411687
• NCI Thesaurus Code: C81408
• Metabolomics Workbench ID: 49736
• ChEMBL ID: CHEMBL280802
• Mol file: 90-01-7.mol

Synonyms:2-methylol phenol;2-monomethylolphenol;o-hydroxybenzyl alcohol;salicyl alcohol;salicyl alcohol, (ar)-isomer;salicyl alcohol, disodium salt;salicyl alcohol, monosodium salt;saligenin

Chemical Property of Salicyl alcohol

Chemical Property:

• Appearance/Colour: light brown crystalline powder
• Vapor Pressure: 0.00404mmHg at 25°C
• Melting Point: 83-85 °C(lit.)
• Refractive Index: 1.595
• Boiling Point: 267.5 °C at 760 mmHg
• PKA: pK1:9.92 (25°C)
• Flash Point: 133.7 °C
• PSA: 40.46000
• Density: 1.22 g/cm³
• LogP: 0.88450
• Storage Temp.: Store below +30°C.
• Solubility.: ethanol: soluble5%, clear to very slightly hazy, colorless to li
• Water Solubility.: 67 g/L (22 ºC)
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 124.052429494
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

99% ^*data from raw suppliers

2-Hydroxybenzyl Alcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Phenols
• Canonical SMILES: C1=CC=C(C(=C1)CO)O
• Uses: anesthetic (local), antiinflammatory 2-Hydroxybenzyl Alcohol is a phenolic component of a part of a salix bark extract which maintains a minor anti-depressant effect. Phenolic analog with potential for anti-melanomic effect. Also?It is an intermediate in the production of phenol formaldehyde res ins (may remain after condensation of the resin); sensitizer in phenol-formaldehyde resins; in loeal anesthetics.

Technology Process of Salicyl alcohol

There total 161 articles about Salicyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + phenol (108-95-2,27073-41-2) → 4H-benzo[1,3]dioxine (254-27-3) + (4-hydroxyphenyl)methanol (623-05-2) + salicylic alcohol (90-01-7)

Guidance literature:

With hydrogenchloride; acetic acid; at 65 ℃; for 20h;

Reference yield: 65.5%

ortho-cresol (95-48-7,77504-84-8) → salicylic alcohol (90-01-7) + salicylaldehyde (90-02-8) + salicylic acid (69-72-7,25496-36-0,8052-31-1)

Guidance literature:

With dihydrogen peroxide; In methanol; water; at 60 ℃; for 2h; Reagent/catalyst; Molecular sieve;

Reference yield: 10.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + phenol (108-95-2,27073-41-2) → (4-hydroxyphenyl)methanol (623-05-2) + salicylic alcohol (90-01-7)

Guidance literature:

With sodium metaborate tetrahydrate; In water; at 60 ℃; regioselective reaction; Green chemistry;

DOI:10.1039/c4ob00228h

upstream raw materials:

2-Aminobenzyl alcohol

3,5-dichloro-2-hydroxybenzyl alcohol

2-hydroxy-3,5-dibromobenzenemethanol

carbonic acid bis-(2-chloromethyl-phenyl ester)

Downstream raw materials:

flavan

5-methyl-2-salicyl-resorcinol

2-(2-piperidino-ethoxy)-benzyl alcohol

2-(2-hydroxymethyl-phenoxymethyl)-5-methoxy-pyran-4-one

Refernces

• 1、 Bergner, Magnus,Duquette, Douglas C.,Chio, Linda,Stoltz, Brian M.. "Exceedingly Efficient Synthesis of (±)-Grandifloracin and Acylated Analogues". . p. 3008 - 3010. Retrieved 2015.
• 2、 Suchocki, John C.,Sneden, ALbert T.. "New Maytansinoids: Reduction Products of the C(9) Carbinolamide". . p. 4116 - 4118. Retrieved 1988.
• 3、 -. "PNO ligand containing planar chiral ferrocene and application thereof". Paragraph 0114-0118. . Retrieved 2021/06/21.
• 4、 Li, Xinying,Mi, Tongge,Guo, Wenjing,Ruan, Zhongrui,Guo, Yu,Ma, Yan-Na,Chen, Xuenian. "KB3H8: An environment-friendly reagent for the selective reduction of aldehydes and ketones to alcohols". supporting information. p. 12776 - 12779. Retrieved 2021/12/10.