1-(2,3-Dichlorophenyl)piperazine hydrochloride

Base Information

• Chemical Name: 1-(2,3-Dichlorophenyl)piperazine hydrochloride
• CAS No.: 119532-26-2
• Molecular Formula: C₁₀H₁₂Cl₂N₂*ClH
• Molecular Weight: 267.586
• Hs Code.: 29339900
• European Community (EC) Number: 601-621-5,630-331-1
• UNII: QC5R44625J
• DSSTox Substance ID: DTXSID50866037
• Mol file: 119532-26-2.mol

Synonyms:1-(2,3-Dichlorophenyl)piperazine hydrochloride;119532-26-2;1-(2,3-Dichlorophenyl)piperazine monohydrochloride;1-(2,3-Dichlorophenyl)piperazine HCl;1-(2,3-dichlorophenyl)piperazine;hydrochloride;1-(2,3-Dichlorophenyl)-piperazine hydrochloride;Piperazine, 1-(2,3-dichlorophenyl)-, monohydrochloride;N-(2,3-Dichlorophenyl)piperazine Hydrochloride;EC 601-621-5;1-(2,3-Dichlorophenyl)piperazine, HCl;Piperazine, 1-(2,3-dichlorophenyl)-, hydrochloride (1:1);C10H13Cl3N2;1-(2,3-dichlorophenyl)-piperazine monohydrochloride;2,3-dichlorophenylpiperazine hydrochloride;1-(2,3-Dichlorophenyl)piperazinehydrochloride;SCHEMBL246338;AMY3595;DTXSID50866037;CYQFNNSFAGXCEC-UHFFFAOYSA-N;QC5R44625J;BCP08858;LT0049;MFCD00190238;AKOS015845866;1-(2,3-Dichloorphenyl)piperazine HCL;AC-7247;CS-W023109;AS-10761;PD019425;SY005342;2,3-dichlorophenyl piperazine hydrochloride;2,3-dichlorophenyl-piperazine hydrochloride;D3660;FT-0600910;NS00078092;1-(2,3-dichloro-phenyl)piperazine hydrochloride;1-(2,3-dichlorophenyl)piperazine, hydrochloride;EN300-1265350;1-(2,3-dichloro-phenyl)-piperazine hydrochloride;1-(2,3-Diclorophenyl)piperazine monohydrochloride;A926926;1-(2,3-dichlorophenyl)piperazine hydrochloride salt;1-(2,3-dichlorophenyl)piperazine mono hydrochloride;J-502893;J-502894;Piperazine, 1-(2,3-dichlorophenyl)-, hydrochloride;1-(2,3-Dichlorophenyl)piperazine hydrochloride, 97%;F2190-0526;Z1954804512

Chemical Property of 1-(2,3-Dichlorophenyl)piperazine hydrochloride

Chemical Property:

• Appearance/Colour: Off-White Solid
• Vapor Pressure: 1.77E-07mmHg at 25°C
• Melting Point: 245-247 °C
• Boiling Point: 365.1 °C at 760 mmHg
• Flash Point: 174.6 °C
• PSA: 15.27000
• Density: 1.272g/cm3
• LogP: 3.59880
• Storage Temp.: Room temperature.
• Sensitive.: Hygroscopic
• Water Solubility.: Soluble in water, DMSO and methanol.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 266.014432
• Heavy Atom Count: 15
• Complexity: 183

Purity/Quality:

99%min. ^*data from raw suppliers

1-(2,3-Dichlorophenyl)piperazine Hydrochloride >98.0%(HPLC)(N) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C2=C(C(=CC=C2)Cl)Cl.Cl
• Uses: This product is intended for forensic and research purposes and it is an aripiprazole intermediate. Aripiprazole (A771000) intermediate.

Technology Process of 1-(2,3-Dichlorophenyl)piperazine hydrochloride

There total 9 articles about 1-(2,3-Dichlorophenyl)piperazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-(2,3-dichlorophenyl)piperazine-1-carboxylate → 1-(2,3-dichlorophenyl)-piperazine hydrochloride (119532-26-2,864512-47-0)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 2h;

Reference yield: 89.0%

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + 2,3-dichloroaniline (608-27-5) → 1-(2,3-dichlorophenyl)-piperazine hydrochloride (119532-26-2,864512-47-0)

Guidance literature:

In sulfolane; at 150 ℃; for 14h; Solvent;

DOI:10.1016/j.tetlet.2015.06.003

Reference yield: 77.0%

C15H22ClN3O → 1-(2,3-dichlorophenyl)-piperazine hydrochloride (119532-26-2,864512-47-0)

Guidance literature:

C₁₅H₂₂ClN₃O; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

With copper(l) chloride; In water; at 52 - 100 ℃; for 12h;

upstream raw materials:

1-bromo-2,3-dichlorobenzene

bis-(2-chloroethyl)amine hydrochloride

2,3-dichloroaniline

morpholine

Downstream raw materials:

2-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

2-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]-2-hydroxypropyl]isoindoline-1,3-dione

2-{3-[4-(2,3-dichlorophenyl)piperazin-1-yl]propyl}-1H-isoindole-1,3(2H)-dione

2-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione

Refernces

• 1、 -. "Synthesis method of cariprazine key intermediate 1-(2,3-dichlorophenyl)piperazine hydrochloride". Paragraph 0042-0044; 0051-0056. . Retrieved 2021/11/26.
• 2、 -. "Preparation method of 1-(2,3-dichlorophenyl)piperazine hydrochloride". Paragraph 0011; 0012. . Retrieved 2019/06/08.