Technology Process of (5-((2-(1H-imidazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methanamine hydrochloride
There total 5 articles about (5-((2-(1H-imidazol-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methanamine hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
diethyl ether;
at 0 - 20 ℃;
for 12h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate; potassium iodide / acetone / 8 h / Reflux
2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 20 °C
2.2: 36 h / 20 °C
3.1: hydrogenchloride / diethyl ether / 12 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; N-chloro-succinimide; potassium carbonate; potassium iodide;
In
diethyl ether; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: boron tribromide / dichloromethane / 8 h / -10 - 20 °C
2.1: potassium carbonate; potassium iodide / acetone / 8 h / Reflux
3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 20 °C
3.2: 36 h / 20 °C
4.1: hydrogenchloride / diethyl ether / 12 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; N-chloro-succinimide; boron tribromide; potassium carbonate; potassium iodide;
In
diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone;
