(S)-(-)-3-Amino-3-phenylpropionic acid hydrochloride

Base Information

• Chemical Name: (S)-(-)-3-Amino-3-phenylpropionic acid hydrochloride
• CAS No.: 83649-47-2
• Molecular Formula: C9H12ClNO2
• Molecular Weight: 201.65
• Hs Code.: 2922499990
• Mol file: 83649-47-2.mol

Synonyms:Benzenepropanoicacid, b-amino-, hydrochloride, (S)-;Benzenepropanoic acid, b-amino-, hydrochloride, (bS)- (9CI);(S)-3-Amino-3-phenylpropionic acid hydrochloride;(S)-3-Amino-3-phenylpropionic acid;

Chemical Property of (S)-(-)-3-Amino-3-phenylpropionic acid hydrochloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powde
• Vapor Pressure: 3.83E-05mmHg at 25°C
• Melting Point: 179-184 °C
• Boiling Point: 338.4 °C at 760 mmHg
• Flash Point: 158.5 °C
• PSA: 63.32000
• LogP: 2.66340
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Methanol, Water

Purity/Quality:

99%, ^*data from raw suppliers

(S)-3-Phenyl-β-alanineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 45-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-3-Phenyl-β-alanine Hydrochloride (cas# 83649-47-2) is a compound useful in organic synthesis.

Technology Process of (S)-(-)-3-Amino-3-phenylpropionic acid hydrochloride

There total 24 articles about (S)-(-)-3-Amino-3-phenylpropionic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(3S)-methyl 3-amino-3-phenylpropanoate (37088-66-7) → (S)-(-)-β-Phenyl-β-alanine hydrochloride (83649-47-2)

Guidance literature:

With hydrogenchloride; sodium hydroxide; for 16h; Ambient temperature;

DOI:10.1016/S0040-4020(01)92138-6

Reference yield: 74.0%

(S)-N-(4-Nitrobenzyloxycarbonyl)-β-phenyl-β-alanine (137050-87-4) → (S)-(-)-β-Phenyl-β-alanine hydrochloride (83649-47-2)

Guidance literature:

With hydrogenchloride; In diethyl ether; for 18h; Ambient temperature;

DOI:10.1021/jo00020a033

Reference yield: 74.0%

(S)-(+)-β-phenyl-β-alanine methyl ester hydrochloride → (S)-(-)-β-Phenyl-β-alanine hydrochloride (83649-47-2)

Guidance literature:

With sodium hydroxide; for 3h;

upstream raw materials:

D-3-(N-formylamino)-3-phenylpropionic acid

(3S)-methyl 3-amino-3-phenylpropanoate

(S)-N-(4-Nitrobenzyloxycarbonyl)-β-phenyl-β-alanine

3-(tert-butoxycarbonylamino)-3-phenylpropanoic acid

Downstream raw materials:

ethyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-phenylpropanoate

ethyl (3S)-3-amino-3-phenylpropionate

(S)-4-phenyl-2-azetidinone

(3S)-N-(benzyloxycarbonyl)-3-amino-3-phenylpropanoic acid

Refernces

• 1、 Lai, Junshan,Sayalero, Sonia,Ferrali, Alessandro,Osorio-Planes, Laura,Bravo, Fernando,Rodríguez-Escrich, Carles,Pericàs, Miquel A.. "Immobilization of cis-4-Hydroxydiphenylprolinol Silyl Ethers onto Polystyrene. Application in the Catalytic Enantioselective Synthesis of 5-Hydroxyisoxazolidines in Batch and Flow". supporting information. p. 2914 - 2924. Retrieved 2018/08/17.
• 2、 Wang, Li,Shen, Chun,Xu, Ming-Hua. "SmI2-promoted imino-Reformatsky reaction for facile synthesis of enantioenriched β-amino acid esters". . p. 61 - 65. Retrieved 2011/12/15.