N-hydroxy-4-methoxybenzenecarboximidoyl chloride

Base Information

• Chemical Name: N-hydroxy-4-methoxybenzenecarboximidoyl chloride
• CAS No.: 74903-79-0
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Mol file: 74903-79-0.mol

Synonyms:N-hydroxy-4-methoxybenzenecarboximidoyl chloride

Chemical Property of N-hydroxy-4-methoxybenzenecarboximidoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-hydroxy-4-methoxybenzenecarboximidoyl chloride

There total 8 articles about N-hydroxy-4-methoxybenzenecarboximidoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-methoxyl benzaldoxime (3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9) → N-hydroxy-4-methoxybenzenecarboximidoyl chloride (74903-79-0)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/ja0471525

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → N-hydroxy-4-methoxybenzenecarboximidoyl chloride (74903-79-0)

Guidance literature:

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; Yield given. Multistep reaction; 1.) CH₂Cl₂, 2.) DMF;

DOI:10.1021/jo9807621

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → N-hydroxy-4-methoxybenzenecarboximidoyl chloride (74903-79-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; pyridine / ethanol

2: N-chlorosuccinimide; HCl / dimethylformamide / 20 °C

With pyridine; hydrogenchloride; N-chloro-succinimide; hydroxylamine hydrochloride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.10.062

upstream raw materials:

(E)-4-methoxybenzaldoxime

4-methoxy-benzaldehyde

4-methoxy-benzaldehyde-(O-methyl-seqtrans-oxime )

p-methoxyl benzaldoxime

Downstream raw materials:

methyl 4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl ether

3,5-bis(4-methoxyphenyl)-1,2,4-oxadiazole 4-oxide

3-anisyl-5-phenyl-1,2,4-oxadiazole-4-oxide

[3-(4-methoxyphenyl)-4,5-dihydro-isoxazol-5-yl]phosphonic acid diethyl ester

Refernces

• 1、 Li, Xiaojuan,Ni, Shengyang,Pan, Yi,Wang, Yi,Zhang, Qiang,Zhang, Weigang. "Decarboxylative Borylation of Stabilized and Activated Carbon Radicals". . p. 21875 - 21879. Retrieved 2020/10/02.
• 2、 Pirali, Tracey,Mossetti, Riccardo,Galli, Simona,Tron, Gian Cesare. "Stereospecific synthesis of syn -α-oximinoamides by a three-component reaction of isocyanides, syn -chlorooximes, and carboxylic acids". . p. 3734 - 3737. Retrieved 2011/09/15.