(2-aminophenyl)diphenylmethanol

Base Information

• Chemical Name: (2-aminophenyl)diphenylmethanol
• CAS No.: 52744-72-6
• Molecular Formula: C₁₉H₁₇NO
• Molecular Weight: 275.35
• Mol file: 52744-72-6.mol

Synonyms:(2-aminophenyl)diphenylmethanol

Chemical Property of (2-aminophenyl)diphenylmethanol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-aminophenyl)diphenylmethanol

There total 20 articles about (2-aminophenyl)diphenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

bromobenzene (108-86-1,52753-63-6) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → (2-aminophenyl)diphenylmethanol (52744-72-6)

Guidance literature:

bromobenzene; With magnesium; In diethyl ether; at 25 ℃;

(2-aminophenyl)(phenyl)methanone; In tetrahydrofuran; diethyl ether; at 0 - 25 ℃; for 2h;

DOI:10.1021/jacs.9b12698

Reference yield: 97.0%

phenylmagnesium bromide (100-58-3) + (2-aminophenyl)(phenyl)methanone (2835-77-0) → (2-aminophenyl)diphenylmethanol (52744-72-6)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 20 ℃; for 2h;

DOI:10.1002/ejoc.201501356

Reference yield: 89.0%

(2-azidophenyl)(phenyl)methanone (16714-27-5) + phenylmagnesium bromide (100-58-3) → (2-aminophenyl)diphenylmethanol (52744-72-6)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1039/d0cc05031h

upstream raw materials:

acetic acid-[2-(α-hydroxy-benzhydryl)-anilide]

2-carbomethoxyaniline

4,4-diphenyl-1,4-dihydro-3,1-benzoxazin-2(1H)-one

2-formamidotriphenylmethanol

Downstream raw materials:

2-methyl-4,4-diphenyl-4H-benzo[d][1,3]oxazine

acetic acid-[2-(α-hydroxy-benzhydryl)-anilide]

(4,4-diphenyl-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-yl)-phenyl-acetonitrile

(2-iodophenyl)diphenylmethanol

Refernces

• 1、 Man, Ningning,Lou, Zhenbang,Li, Yuming,Yang, Haijun,Zhao, Yufen,Fu, Hua. "Organocatalytic Atroposelective Construction of Axially Chiral N-Aryl Benzimidazoles Involving Carbon-Carbon Bond Cleavage". supporting information. p. 6382 - 6387. Retrieved 2020/09/02.
• 2、 Del Vecchio, Antonio,Talbot, Alex,Caillé, Fabien,Chevalier, Arnaud,Sallustrau, Antoine,Loreau, Olivier,Destro, Gianluca,Taran, Frédéric,Audisio, Davide. "Carbon isotope labeling of carbamates by late-stage [11C], [13C] and [14C]carbon dioxide incorporation". supporting information. p. 11677 - 11680. Retrieved 2020/10/19.