Clindamycin hydrochloride monohydrate

Base Information

• Chemical Name: Clindamycin hydrochloride monohydrate
• CAS No.: 58207-19-5
• Molecular Formula: C₁₂H₂₀O₂
• Molecular Weight: 196.29
• Hs Code.: 29419090
• UNII: ZNC153389R
• Wikidata: Q27295770
• NCI Thesaurus Code: C83630
• Mol file: 58207-19-5.mol

Synonyms:Clindamycin hydrochloride monohydrate;58207-19-5;CLINDAMYCIN ALCOHOLATE;Clindamycin HCl monohydrate;ZNC153389R;Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-l-threo-alpha-d-galacto-octopyranoside monohydrochloride, monohydrate;Clindamycin hydrochloride hydrate;(2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrate;hydrochloride;UNII-ZNC153389R;Clindamycin (hydrochloride monohydrate);threo-alpha-d-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, monohydrochloride, monohydrate, (2S-trans)-;SCHEMBL7161659;MFCD06411091;s5420;AKOS015900869;CCG-269538;AS-10145;CLINDAMYCIN MONOHYDROCHLORIDE MONOHYDRATE;D89500;CLINDAMYCIN HYDROCHLORIDE MONOHYDRATE [MI];Q27295770;CLINDAMYCIN MONOHYDROCHLORIDE MONOHYDRATE [WHO-DD];L-THREO-.ALPHA.-D-GALACTO-OCTOPYRANOSIDE, METHYL 7-CHLORO-6,7,8-TRIDEOXY-6-(((1-METHYL-4-PROPYL-2-PYRROLIDINYL)CARBONYL)AMINO)-1-THIO-, MONOHYDROCHLORIDE, MONOHYDRATE,(2S-TRANS)-;METHYL 7-CHLORO-6,7,8-TRIDEOXY-6-(1-METHYL-TRANS-4-PROPYL-L-2-PYRROLIDINECARBOXAMIDO)-1-THIO-L-THREO-.ALPHA.-D-GALACTO-OCTOPYRANOSIDE MONOHYDROCHLORIDE, MONOHYDRATE

Chemical Property of Clindamycin hydrochloride monohydrate

Chemical Property:

• Appearance/Colour: White Crystalline Solid
• Melting Point: 143oC
• Refractive Index: 143 ° (C=2, H2O)
• Boiling Point: 647oC at 760 mmHg
• Flash Point: 345.1oC
• PSA: 136.79000
• LogP: 1.45600
• Storage Temp.: 2-8°C
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 478.1671134
• Heavy Atom Count: 29
• Complexity: 502

Purity/Quality:

99%min ^*data from raw suppliers

Clindamycin Hydrochloride Monohydrate >98.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl.O.Cl
• Isomeric SMILES: CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl.O.Cl
• Uses: An antibiotic Clindamycin hydrochloride monohydrate is an antibacterial agent that is a semisynthetic analog of lincomycin.

Technology Process of Clindamycin hydrochloride monohydrate

There total 2 articles about Clindamycin hydrochloride monohydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-(S)-α-terpineol (10482-56-1,2438-12-2) + acetic anhydride (108-24-7) → (4S)-(-)-α-terpinyl acetate (80-26-2,7785-54-8,10581-37-0,58206-95-4)

Guidance literature:

With cesium 12-tungstophosphate; at 20 ℃; for 0.5h; Time; Catalytic behavior; Green chemistry;

DOI:10.1039/c6ra02266a

Reference yield:

C10H16O + acetic anhydride (108-24-7) → C12H18O2 + (4S)-(-)-α-terpinyl acetate (80-26-2,7785-54-8,10581-37-0,58206-95-4)

Guidance literature:

With cesium 12-tungstophosphate; at 20 ℃; for 0.5h; Time; Catalytic behavior; Green chemistry;

DOI:10.1039/c6ra02266a

upstream raw materials:

(-)-(S)-α-terpineol

acetic anhydride

Refernces