Technology Process of Ribostamycin
There total 15 articles about Ribostamycin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrazine hydrate;
at 100 ℃;
for 66h;
sealed tube;
DOI:10.1246/cl.1984.2097
- Guidance literature:
-
Multi-step reaction with 5 steps
1: benzene; pyridine / 1 h / Heating
2: 62 percent / NaOMe / methanol; nitromethane / 14 h / Ambient temperature
3: 1.) p-TsOH*H2O; 2.) pyridine; 3.) d-10-camphorsulfonic acid / 1.) DMF, 45 deg C, 50 min; 2.) r.t., 8 h; 3.) DMF, r.t., 10 min
5: 59 percent / 80percent aq. NH2NH2*H2O / 66 h / 100 °C / sealed tube
With
pyridine; camphor-10-sulfonic acid; sodium methylate; toluene-4-sulfonic acid; hydrazine hydrate;
In
pyridine; methanol; nitromethane; benzene;
DOI:10.1246/cl.1984.2097
- Guidance literature:
-
Multi-step reaction with 7 steps
1: pyridine
2: 1.) BF3-Et2O; 2.) Jones reagent / 1.) THF, 2 deg C, 40 min; 2.) r.t., 4 h
3: benzene; pyridine / 1 h / Heating
4: 62 percent / NaOMe / methanol; nitromethane / 14 h / Ambient temperature
5: 1.) p-TsOH*H2O; 2.) pyridine; 3.) d-10-camphorsulfonic acid / 1.) DMF, 45 deg C, 50 min; 2.) r.t., 8 h; 3.) DMF, r.t., 10 min
7: 59 percent / 80percent aq. NH2NH2*H2O / 66 h / 100 °C / sealed tube
With
pyridine; jones reagent; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; sodium methylate; toluene-4-sulfonic acid; hydrazine hydrate;
In
pyridine; methanol; nitromethane; benzene;
DOI:10.1246/cl.1984.2097
