Chemical Property of NEOMYCIN SULFATE
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Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:250 °C (decomp)
- Boiling Point:927.064 °C at 760 mmHg
- Flash Point:514.47 °C
- PSA：602.05000
- Density:1.616 g/cm3
- LogP:-3.40950
- Storage Temp.:2-8°C
- Solubility.:H2O: 50 mg/mL As a stock solution. Stock solutions should b
- Purity/Quality:
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98%,99%, *data from raw suppliers
Neomycin *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
42/43
- Safety Statements:
22-36/37-45
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
Neomycin is an antibiotic from the aminoglycoside
group, and has two isomers - neomycin Band
neomycin C. Occupational contact dermatitis mainly
occurs in workers at animal-feed mills, in veterinaries
and in health workers.
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Uses
Neomycin, like streptomycin, has a broad spectrum of antibacterial activity. It is effective
with respect to the majority of Gram-negative and a few Gram-positive bacteria; staphylococci, pneumococci, gonococci, meningococci, and stimulants of dysentery. It is not very
active with respect to streptococci. The antibiotic effect of neomycin with respect to many
types of bacteria is higher than that of streptomycin. At the same time, microorganisms
sensitive to neomycin become resistant to a lesser degree than streptomycin.
It is used for various gastrointestinal diseases caused by microorganisms sensitive to it,
including enteritis, which is caused by microbes that are resistant to antibiotics. However,
because of its high oto- and nephrotoxicity, its local use is preferred for infected skin diseases, infected wounds, conjunctivitis, keratitis, and others. Synonyms of this drug are
framycetin, soframycin, tautomycin, and others. Neomycin is an antibiotic. Antibacterial; antifungal.
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Therapeutic Function
Antibacterial
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Clinical Use
Superficial infections with staphylococci and Gram-negative bacilli
(topical; alone or in combination with bacitracin, chlorhexidine or
polymyxin)
Treatment of staphylococcal nasal carriers (topical, in combination with
chlorhexidine or bacitracin)
Eye infections (topical; alone or in combination)
Otitis externa (alone or with a corticosteroid)
Gut decontamination before abdominal surgery (oral)
Prophylaxis after urinary tract instrumentation (instillation)
Use is discouraged because of the possibility of promoting the
appearance of aminoglycoside-resistant strains, and because
of the risk of absorption with the consequent danger of systemic
toxicity or neuromuscular blockade.
