4,4'-Bis(dimethylamino)thiobenzophenone

Base Information

• Chemical Name: 4,4'-Bis(dimethylamino)thiobenzophenone
• CAS No.: 1226-46-6
• Molecular Formula: C17H20N2S
• Molecular Weight: 284.425
• Hs Code.: 29309070
• European Community (EC) Number: 214-962-6
• NSC Number: 30656
• UNII: P27X4MS4EV
• DSSTox Substance ID: DTXSID3061633
• Nikkaji Number: J23.054E
• Wikidata: Q17173074
• Mol file: 1226-46-6.mol

Synonyms:4,4'-bis(dimethylamino)thiobenzophenone;thio-Michler's ketone

Chemical Property of 4,4'-Bis(dimethylamino)thiobenzophenone

Chemical Property:

• Appearance/Colour: Yellow or off-white solid.
• Melting Point: 202-206 °C(lit.)
• Boiling Point: 429.958 °C at 760 mmHg
• PKA: 3.05±0.24(Predicted)
• Flash Point: 213.831 °C
• PSA: 38.57000
• Density: 1.131 g/cm³
• LogP: 3.58490
• Storage Temp.: Store below +30°C.
• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 284.13471982
• Heavy Atom Count: 20
• Complexity: 281

Purity/Quality:

98%,99%, ^*data from raw suppliers

Thiomichler's Ketone [Sensitive spectrophotometric reagent for Au, Ag, Hg and Pd, use for the determination of residual chlorine] >97.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Aromatics (Nitrogen)
• Canonical SMILES: CN(C)C1=CC=C(C=C1)C(=S)C2=CC=C(C=C2)N(C)C

Technology Process of 4,4'-Bis(dimethylamino)thiobenzophenone

There total 25 articles about 4,4'-Bis(dimethylamino)thiobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

bis(p-dimethylaminophenyl)methanone (90-94-8) → thiomichlersketone (1226-46-6)

Guidance literature:

With aluminum oxide; tetraphosphorus decasulfide; In acetonitrile; for 0.5h; Heating;

DOI:10.1016/j.tetlet.2004.06.091

Reference yield: 95.0%

bis<4-dimethylaminophenyl> sulfine (78594-04-4) → thiomichlersketone (1226-46-6)

Guidance literature:

With tetraphosphorus decasulfide; In dichloromethane; at 25 ℃; for 1h;

DOI:10.1055/s-1981-29423

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → thiomichlersketone (1226-46-6) + tris[4-(dimethylamino)phenyl]methane (603-48-5)

Guidance literature:

With zinc(II) chloride; at 80 ℃;

upstream raw materials:

carbon disulfide

auramine O

4,4'-(aminomethylene)bis(N,N-dimethylaniline)

4,4'-methylene-bis(N,N-dimethylaniline)

Downstream raw materials:

2,2-bis-(4-chloro-phenyl)-3,3-bis-(4-dimethylamino-phenyl)-thiirane

2,2-bis-(4-dimethylamino-phenyl)-3,3-di-p-tolyl-thiirane

1-biphenyl-4-yl-2,2-bis-(4-dimethylamino-phenyl)-1-phenyl-ethene

N-methylene>aniline

Refernces

• 1、 Tarbell,Wystrach. "-". . p. 2110. Retrieved 1946.
• 2、 -. "A thionation process and a thionating agent". Page/Page column 10. . Retrieved 2012/08/14.