Linuron

Base Information

• Chemical Name: Linuron
• CAS No.: 330-55-2
• Deprecated CAS: 56645-87-5
• Molecular Formula: C9H10Cl2N2O2
• Molecular Weight: 249.097
• Hs Code.: 29280000
• European Community (EC) Number: 206-356-5
• ICSC Number: 1300
• UN Number: 3077,2588
• UNII: 01XP1SU59O
• DSSTox Substance ID: DTXSID2024163
• Nikkaji Number: J3.277H
• Wikipedia: Linuron
• Wikidata: Q421476
• Metabolomics Workbench ID: 67580
• ChEMBL ID: CHEMBL448213
• Mol file: 330-55-2.mol

Synonyms:Afalon;Linuron

Chemical Property of Linuron

Chemical Property:

• Appearance/Colour: colorless crystals
• Melting Point: 93-94 °C
• Refractive Index: 1.6
• Boiling Point: 180-190 °C
• PKA: 12.13±0.70(Predicted)
• Flash Point: 11 °C
• PSA: 41.57000
• Density: 1.41 g/cm³
• LogP: 3.09150
• Storage Temp.: APPROX 4°C
• Water Solubility.: 0.0075 g/100 mL
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 248.0119330
• Heavy Atom Count: 15
• Complexity: 228
• Transport DOT Label: Class 9

Purity/Quality:

99% ^*data from raw suppliers

Linuron ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, N
• Hazard Codes: T;N,N,T,F
• Statements: 61-22-40-48/22-50/53-62-39/23/24/25-23/24/25-11
• Safety Statements: 53-45-60-61-36/37-16-7

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Pesticides -> Herbicides, Urea Derivative
• Canonical SMILES: CN(C(=O)NC1=CC(=C(C=C1)Cl)Cl)OC
• Inhalation Risk: Evaporation at 20 °C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered.
• Effects of Long Term Exposure: The substance may have effects on the blood. This may result in anaemia.
• Description: Linuron is found as white crystals that have no smell. It is very slightly soluble in water. Linuron can enter the body either by ingestion of contaminated food or water or by dermal contact. Linuron can cause nausea, vomiting, and diarrhea. Eye contact can cause irritation. There is little evidence available as to the effects of exposure to linuron on human health. However, exposure to linuron at normal background levels is unlikely to have any adverse effect on human health.
• Uses: Selective preemergence and postemergence herbicide used on a wide variety of food crops to control many annual broad-leaved and grass weeds. Linuron is used to control annual and perennial broadleaf and grassy weeds on crop and noncrop sites. It is used as a pre- and post-emergent herbicide. It works by inhibiting photosynthesis in target weed plants. It is used in soybean, cotton, potato, corn, bean, pea, winter wheat, asparagus, carrot, and fruit crops. It is also used on crops stored in warehouses and storerooms. Linuron is classified by the US Environmental Protection Agency (EPA) as a Restricted Use Pesticide (RUP). Selective pre- and post-emergence herbicide. A restricted use pesticide. Herbicide.

Technology Process of Linuron

There total 4 articles about Linuron which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dichlorophenylisocyanate (102-36-3) → N'-(3,4-dichlorophenyl)-N-methoxy-N-methylurea (330-55-2)

Guidance literature:

Multi-step reaction with 2 steps

2: aq. NaOH / methanol

With sodium hydroxide; In methanol;

Reference yield:

1-(3,4-dichlorophenyl)-3-methoxyurea (17356-61-5) + dimethyl sulfate (77-78-1) → N'-(3,4-dichlorophenyl)-N-methoxy-N-methylurea (330-55-2)

Guidance literature:

With sodium hydroxide; In methanol;

Reference yield:

1-(3,4-dichlorophenyl)-3-hydroxyurea (31225-17-9) + dimethyl sulfate (77-78-1) → N'-(3,4-dichlorophenyl)-N-methoxy-N-methylurea (330-55-2)

Guidance literature:

With sodium hydroxide; In methanol;

upstream raw materials:

1-(3,4-dichlorophenyl)-3-methoxyurea

dimethyl sulfate

1-(3,4-dichlorophenyl)-3-hydroxyurea

3,4-dichlorophenylisocyanate

Downstream raw materials:

methylamine

Refernces

• 1、 -. "USE OF GLYCEROL ETHERS AS ACTIVATORS OF THE BIOLOGICAL EFFECTS OF A HERBICIDE, FUNGICIDE OR INSECTICIDE SUBSTANCE". . . Retrieved 2012/09/05.
• 2、 -. "Herbicidal composition for upland farming and weeding method". . . Retrieved 2008/06/13.