Bisoprolol

Base Information

• Chemical Name: Bisoprolol
• CAS No.: 66722-44-9
• Molecular Formula: C18H31NO4
• Molecular Weight: 325.44
• Hs Code.: 2922509090
• European Community (EC) Number: 613-980-5
• UNII: Y41JS2NL6U
• DSSTox Substance ID: DTXSID6022682
• Nikkaji Number: J32.485J
• Wikipedia: Bisoprolol
• Wikidata: Q412515
• NCI Thesaurus Code: C61653
• RXCUI: 19484
• Pharos Ligand ID: KYL32DCFZQT9
• Metabolomics Workbench ID: 42941
• ChEMBL ID: CHEMBL645
• Mol file: 66722-44-9.mol

Synonyms:Bisoprolol;Bisoprolol Fumarate;Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer;Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer;Bisoprolol Hydrochloride;Bisoprolol Methanesulfonate Salt;Bisoprolol, (+-)-Isomer;Bisoprolol, (-)-Isomer;Bisoprolol, Fumarate (1:1) Salt;Bisoprolol, Fumarate (2:1) Salt;CL 297939;CL-297939;CL297939;Concor;EMD 33512;EMD-33512;EMD33512;Fumarate, Bisoprolol;Hydrochloride, Bisoprolol

Chemical Property of Bisoprolol

Chemical Property:

• Appearance/Colour: Yellow oil
• Melting Point: 100 °C
• Boiling Point: 445.026 °C at 760 mmHg
• PKA: pKa 9.57(H2O(extrap) t=25±1 Iunde?ned Aratmosphere) (Uncertain)
• Flash Point: 222.944 °C
• PSA: 59.95000
• Density: 1.033 g/cm³
• LogP: 2.75680
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)
• Water Solubility.: 5.5ug/L(100 oC)
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 12
• Exact Mass: 325.22530847
• Heavy Atom Count: 23
• Complexity: 278

Purity/Quality:

99% ^*data from raw suppliers

Cardensiel ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Drug Classes: Beta-Adrenergic Receptor Antagonists
• Canonical SMILES: CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
• Recent ClinicalTrials: Preventing Adverse Cardiac Events in COPD
• Recent EU Clinical Trials: Treatment effects of Bisoprolol and Verapamil in symptomatic patients with non-obstructive hypertrophic cardiomyopathy
• Recent NIPH Clinical Trials: Efficiency evaluation of coronary computed tomography by using transdermal patch beta-blocker (high rate)
• Uses: It is used for the treatment of cardiovascular and cerebrovascular diseases. Cardensiel is an intermediate in the synthesis of 3,3''-(Isopropylazanediyl)bis(1-(4-((2-isopropoxyethoxy)methyl)phenoxy)propan-2-ol) (I824005), which is an impurtiy of Bisoprolol (B510500), a selective β-adrenergic blocker. Used as an antihypertensive.