2-FLUORO-D-PHENYLALANINE

Base Information

• Chemical Name: 2-FLUORO-D-PHENYLALANINE
• CAS No.: 97731-02-7
• Molecular Formula: C9H10FNO2
• Molecular Weight: 183.182
• Hs Code.: 2922499990
• Mol file: 97731-02-7.mol

Synonyms:D-2-Fluorophenylalanine;o-Fluoro-D-phenylalanine;

Chemical Property of 2-FLUORO-D-PHENYLALANINE

Chemical Property:

• Melting Point: 209-211℃
• Boiling Point: 308.1 °C at 760 mmHg
• PKA: 2.21±0.10(Predicted)
• Flash Point: 140.1 °C
• PSA: 63.32000
• Density: 1.293 g/cm³
• LogP: 1.48040
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-(2-Fluorophenyl)alanine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUORO-D-PHENYLALANINE

There total 24 articles about 2-FLUORO-D-PHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-fluoro-(RS)-phenylalaninamide hydrochloride (1428149-29-4) → (R)-2'-fluorophenylalanine (97731-02-7,325-69-9)

Guidance literature:

With pyridoxal 5'-phosphate monohydrate; In aq. buffer; at 40 ℃; for 8h; pH=8.0; Enzymatic reaction;

DOI:10.1002/adsc.201100923

Reference yield: 95.0%

2-(Benzhydrylidene-amino)-3-(2-fluoro-phenyl)-propionic acid methyl ester (145243-39-6) → (R)-2'-fluorophenylalanine (97731-02-7,325-69-9)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jo00056a033

Reference yield: 52.0%

2-fluorocinnamic acid (451-69-4) → (R)-2'-fluorophenylalanine (97731-02-7,325-69-9)

Guidance literature:

With ammonium hydroxide; borane-ammonia complex; In aq. buffer; at 37 ℃; pH=9.6; Enzymatic reaction;

DOI:10.1002/anie.201410670

upstream raw materials:

N-acetyl-2-fluoro-D-phenylalanine

Sodium; 3-(2-fluoro-phenyl)-2-oxo-propionate

2-(Benzhydrylidene-amino)-3-(2-fluoro-phenyl)-propionic acid methyl ester

2-fluoro-DL-phenylalanine

Downstream raw materials:

Fmoc-D-2-fluorophenylalanine

C₉H₁₂FNO

C₂₀H₁₆FNO₃

Refernces

• 1、 Danalev, Dancho,Borisova, Desislava,Yaneva, Spaska,Georgieva, Maya,Balacheva, Anelia,Dzimbova, Tatyana,Iliev, Ivan,Pajpanova, Tamara,Zaharieva, Zdravka,Givechev, Ivan,Naydenova, Emilia. "Synthesis, in vitro biological activity, hydrolytic stability and docking of new analogs of BIM-23052 containing halogenated amino acids". . p. 1581 - 1592. Retrieved 2020/11/23.
• 2、 Walton, Curtis J. W.,Parmeggiani, Fabio,Barber, Janet E. B.,McCann, Jenna L.,Turner, Nicholas J.,Chica, Roberto A.. "Engineered Aminotransferase for the Production of d-Phenylalanine Derivatives Using Biocatalytic Cascades". . p. 470 - 474. Retrieved 2017/12/15.