rac-1-methoxy-4-(1-nitropropan-2-yl)benzene

Base Information

• Chemical Name: rac-1-methoxy-4-(1-nitropropan-2-yl)benzene
• CAS No.: 70360-85-9
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• Mol file: 70360-85-9.mol

Synonyms:rac-1-methoxy-4-(1-nitropropan-2-yl)benzene

Chemical Property of rac-1-methoxy-4-(1-nitropropan-2-yl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of rac-1-methoxy-4-(1-nitropropan-2-yl)benzene

There total 10 articles about rac-1-methoxy-4-(1-nitropropan-2-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C10H11NO3 (181058-95-7) → rac-1-methoxy-4-(1-nitropropan-2-yl)benzene (70360-85-9)

Guidance literature:

With formic acid; ethanol; C₁₉H₂₆ClIrN₃O⁽¹⁺⁾*Cl^(1-); In water; at 80 ℃; for 1h; chemoselective reaction;

DOI:10.1039/d1gc01907d

Reference yield: 82.0%

1-methoxy-4-(2-nitro-vinyl)-benzene (3179-10-0) + methylmagnesium bromide (75-16-1) → rac-1-methoxy-4-(1-nitropropan-2-yl)benzene (70360-85-9)

Guidance literature:

With cerium(III) chloride heptahydrate; In tetrahydrofuran; diethyl ether; at -40 ℃; for 0.166667h; Inert atmosphere;

Reference yield: 71.0%

(E)-1-methoxy-4-(2-nitrovinyl)benzene (3179-10-0,5576-97-6) + methylmagnesium bromide (75-16-1) → rac-1-methoxy-4-(1-nitropropan-2-yl)benzene (70360-85-9)

Guidance literature:

methylmagnesium bromide; With cerium(III) chloride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1.5h; Inert atmosphere;

(E)-1-methoxy-4-(2-nitrovinyl)benzene; In tetrahydrofuran; diethyl ether; at -40 ℃;

DOI:10.1021/acs.jmedchem.8b00052

upstream raw materials:

lysichitalexin

methyl iodide

(E)-1-methoxy-4-(2-nitrovinyl)benzene

4-methoxyphenethyl bromide

Downstream raw materials:

1-amino-2-(4-methoxyphenyl)-propane

(S)-2-(4-methoxyphenyl)propanenitrile

(Z)-2-(4-methoxyphenyl)propanal oxime

(E)-2-(4-methoxyphenyl)propanal oxime

Refernces

• 1、 Chen, Yang,Liu, Changmeng,Xu, Dong,Xu, Jiaxi,Yang, Zhanhui. "Iridium-catalyzed highly chemoselective and efficient reduction of nitroalkenes to nitroalkanes in water". supporting information. p. 6050 - 6058. Retrieved 2021/08/23.
• 2、 Winterton, Sarah E.,Capota, Emanuela,Wang, Xiaoyu,Chen, Hong,Mallipeddi, Prema L.,Williams, Noelle S.,Posner, Bruce A.,Nijhawan, Deepak,Ready, Joseph M.. "Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase". . p. 5199 - 5221. Retrieved 2018/06/13.