Amorolfine hydrochloride

Base Information

• Chemical Name: Amorolfine hydrochloride
• CAS No.: 78613-38-4
• Molecular Formula: C₂₁H₃₅NO*(x)ClH
• Molecular Weight: 353.98
• Hs Code.: 29411010
• European Community (EC) Number: 689-236-9
• UNII: 741YH7379H
• DSSTox Substance ID: DTXSID80229217
• Wikidata: Q27888046
• NCI Thesaurus Code: C81507
• ChEMBL ID: CHEMBL4303363
• Mol file: 78613-38-4.mol

Synonyms:amorolfin hydrochloride;amorolfine;amorolfine hydrochloride;Locéryl;Loceryl;Locetar;Odenil;Ro 14-4767-002;Ro-14-4767-002

Chemical Property of Amorolfine hydrochloride

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 7.75E-07mmHg at 25°C
• Refractive Index: 1.488
• Boiling Point: 407.1 °C at 760 mmHg
• Flash Point: 119.6 °C
• PSA: 12.47000
• Density: 1.234
• LogP: 5.40190
• Storage Temp.: room temp
• Solubility.: DMSO: ≥5mg/mL (warmed)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 353.2485425
• Heavy Atom Count: 24
• Complexity: 336

Purity/Quality:

99% ^*data from raw suppliers

Amorolfine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,N
• Statements: 20/21/22-36/37/38-50/53-38-22
• Safety Statements: 26-36-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2CC(OC(C2)C)C.Cl
• Isomeric SMILES: CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2C[C@H](O[C@H](C2)C)C.Cl
• Recent ClinicalTrials: A Randomized Study to Evaluate the Efficacy of Herbal Ingredients Combined With a Carrier System (Phytonail) Compared With Amorolfine 5% Nail Lacquer (Loceryl) in the Treatment of Toenail Onychomycosis
• Recent EU Clinical Trials: A Randomized, Single-Blinded, Comparative Study of Mycosinate and Curanail in the Treatment of Fungal Nail Infection
• Description: Amorolfine hydrochloride is the first morpholine antifungal agent useful in the topical treatment of onychomycosis. Mechanistically, it appears to inhibit two stages of the ergosterol biosynthetic pathway, which is necessary for fungal cell viability. Active against a broad spectrum of fungi, amorolfiie hydrochloride is particularly effective against yeasts such as Histoplasma capsulatum, dermatophytes and dematiaceous fungi.
• Uses: Amorolfine hydrochloride has been used as an antifungal agent. antihypertensive

Technology Process of Amorolfine hydrochloride

There total 10 articles about Amorolfine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

amorolfine (78613-35-1,288583-04-0,288583-03-9) → amorolfine hydrochloride (78613-38-4)

Guidance literature:

With hydrogenchloride; In ethanol; at 0 - 5 ℃; pH=3 - 4;

Reference yield: 93.36%

amorolfine (78613-35-1,288583-04-0,288583-03-9) → amorolfine hydrochloride (78613-38-4)

Guidance literature:

With hydrogenchloride; In water; isopropyl alcohol; at 20 ℃; for 0.5h; pH=3 - 4;

Reference yield: 77.0%

amorolfine (288583-04-0,288583-03-9) → amorolfine hydrochloride (78613-38-4)

Guidance literature:

With hydrogenchloride; In ethanol; at 10 - 65 ℃;

upstream raw materials:

amorolfine

2-methyl-2-butylchloride

2-methyl-3-(4-(tert-pentyl)phenyl)propanal

cis-2,6-dimethylmorpholine

Refernces

• 1、 -. "Preparation method of chiral morpholine compounds". Paragraph 0004. . Retrieved 2019/02/03.
• 2、 -. "PROCESS FOR THE PURIFICATION OF AMOROLFINE HYDROCHLORIDE". Page/Page column 6. . Retrieved 2011/12/14.