Naftifine Hydrochloride

Base Information

• Chemical Name: Naftifine Hydrochloride
• CAS No.: 65473-14-5
• Molecular Formula: C21H21N^.HCl
• Molecular Weight: 323.86
• Hs Code.: 29214990
• European Community (EC) Number: 620-502-9
• UNII: 25UR9N9041
• ChEMBL ID: CHEMBL1200493
• DSSTox Substance ID: DTXSID2045496
• Metabolomics Workbench ID: 70139
• NCI Thesaurus Code: C47628
• NSC Number: 760068
• RXCUI: 91293
• Wikidata: Q27107497
• Mol file: 65473-14-5.mol

Synonyms:N-cinnamyl-N-methyl-1-naphthalenemethylamine hydrochloride;naftifin;naftifine;naftifine hydrochloride;naftifine hydrochloride, (E)-isomer

Chemical Property of Naftifine Hydrochloride

Chemical Property:

• Melting Point: 172-175°C
• Boiling Point: 440.1 °C at 760 mmHg
• Flash Point: 194.4 °C
• PSA: 3.24000
• LogP: 5.78700
• Storage Temp.: -20?C Freezer
• Solubility.: ethanol: soluble50mg/mL
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 323.1440774
• Heavy Atom Count: 23
• Complexity: 342

Purity/Quality:

99% ^*data from raw suppliers

Naftifine hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CC=CC1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32.Cl
• Isomeric SMILES: CN(C/C=C/C1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32.Cl
• Recent ClinicalTrials: Pediatric Subjects With Tinea Corporis
• Uses: Used as antibiotic drugs, antifungal agents with broad spectrum and strong effect. The curative effect is good and fast with high the safety and survivability. It is for the treatment of dermatophyte infection, superficial moniliasis, Onychomycosis and skin and its accessories (hair finger, fingernail and toe) by achorion, microspore and epidermis Trichophyton. Indications include erasing mycosis of the lower breast as well as erasing mycosis between finger (toes), the buttocks, and the groin.This product has the characteristics of broad antifungal spectrum and low toxicity. Antimycotic allylamine. An antifungal (topical) agent. An antifungal agent
• Description: Naftifine hydrochloride is a topical antifungal agent which acts via inhibiting squalene epoxidase. It demonstrates good activity against Trichophyton, Epidermophyton, Microsporum, Aspergillus, and species. It is the prototype of a significantly improved series of antifungal agents, exemplified by SF 86-327 in which the phenyl group of naftifine has been replaced by t-butylace tylene.
• Clinical Use: Naftifine hydrochloride (Naftin) is available for topical use only in the treatment of cutaneous dermatophyte and Candida infections; it is as effective as topical azoles for these conditions.