Technology Process of (4R,6S)-4-(4-(benzyloxy)-3-methoxyphenethyl)-2,2-dimethyl-6-pentyl-1,3-dioxane
There total 11 articles about (4R,6S)-4-(4-(benzyloxy)-3-methoxyphenethyl)-2,2-dimethyl-6-pentyl-1,3-dioxane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(2-((4R,6S)-2,2-dimethyl-6-pentyl-1,3-dioxan-4-yl)ethyl)-2-methoxyphenol;
With
sodium hydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
Inert atmosphere;
benzyl bromide;
In
tetrahydrofuran;
Inert atmosphere;
DOI:10.1016/j.tetasy.2011.11.010
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium periodate / tetrahydrofuran; water / 1 h
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
2.2: 4 h / -78 - 20 °C
3.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
4.1: hydrogen; palladium(II) hydroxide / benzene / 5 h / 20 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 0 °C / Inert atmosphere
6.1: diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 °C / Inert atmosphere
6.2: 6 h / -78 °C / Inert atmosphere
7.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere
8.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
8.2: Inert atmosphere
With
sodium periodate; n-butyllithium; diethyl methoxy borane; tetrabutyl ammonium fluoride; hydrogen; palladium(II) hydroxide; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; benzene;
DOI:10.1016/j.tetasy.2011.11.010
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2.1: hydrogen; palladium(II) hydroxide / benzene / 5 h / 20 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 0 °C / Inert atmosphere
4.1: diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 °C / Inert atmosphere
4.2: 6 h / -78 °C / Inert atmosphere
5.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere
6.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
6.2: Inert atmosphere
With
diethyl methoxy borane; tetrabutyl ammonium fluoride; hydrogen; palladium(II) hydroxide; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; methanol; dichloromethane; benzene;
DOI:10.1016/j.tetasy.2011.11.010
