cis-Octahydro-isoindole

Base Information

• Chemical Name: cis-Octahydro-isoindole
• CAS No.: 21850-12-4
• Molecular Formula: C8H15N
• Molecular Weight: 125.214
• Hs Code.: 2933990090
• Mol file: 21850-12-4.mol

Synonyms:Isoindoline,hexahydro- (6CI,7CI,8CI);8-Azabicyclo[4.3.0]nonane;Hexahydroisoindoline;Octahydro-1H-isoindole;Perhydroisoindole;

Chemical Property of cis-Octahydro-isoindole

Chemical Property:

• Vapor Pressure: 0.548mmHg at 25°C
• Refractive Index: 1.472
• Boiling Point: 190.2 °C at 760 mmHg
• PKA: 11.53±0.20(Predicted)
• Flash Point: 62.1 °C
• PSA: 12.03000
• Density: 0.915 g/cm³
• LogP: 1.72480
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

Octahydro-isoindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Octahydro-isoindole is used in the preparation of nitrogen containing heterocycles as FGFR inhibitors.

Technology Process of cis-Octahydro-isoindole

There total 2 articles about cis-Octahydro-isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (+/-)-trans-Hexahydroisoindolin (1470-99-1,10479-63-7,21850-12-4)

Guidance literature:

(+-)-trans-2-Chlormethyl-cyclohex-4-en-1-carbonitril, H2, A., Raney-Ni;

Reference yield:

→ trans-Hexahydroisoindolin (1470-99-1,10479-63-7,21850-12-4)

Guidance literature:

entspr.Hydrochlorid;

Reference yield: 90.0%

cycloperhydroisoindole (21850-12-4) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → C14H18N2O2

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Reflux;

DOI:10.1039/d1gc02570h

Downstream raw materials:

phenyl selenocyanate

diphenyl diselenide

1-exo-cyano-cis-octahydroisoindole

C₁₅H₁₈N₂