4,6-Diamino-2-pyrimidinol

Base Information

• Chemical Name: 4,6-Diamino-2-pyrimidinol
• CAS No.: 31458-45-4
• Molecular Formula: C4H6 N4 O
• Molecular Weight: 126.118
• Hs Code.: 2933599090
• Mol file: 31458-45-4.mol

Synonyms:2-Pyrimidinol,4,6-diamino- (8CI); 4,6-Diamino-2-hydroxypyrimidine; 4,6-Diamino-2-pyrimidinol;6-Aminocytosine; NSC 60531

Chemical Property of 4,6-Diamino-2-pyrimidinol

Chemical Property:

• Melting Point: 300 °C
• Boiling Point: 584.1°Cat760mmHg
• PKA: 12.07±0.10(Predicted)
• Flash Point: 307.1°C
• PSA: 98.05000
• Density: 1.84g/cm³
• LogP: 0.50900
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

4,6-Diamino-2-hydroxypyrimidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-Diamino-2-pyrimidinol

There total 2 articles about 4,6-Diamino-2-pyrimidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2,4,6-triaminopyrimidine (1004-38-2) → 4,6-diamino-2-oxopyrimidine (31458-45-4)

Guidance literature:

With hydrogenchloride; for 48h; Heating;

DOI:10.1021/jo0056390

Reference yield:

malonic acid (141-82-2) + guanidine nitrate (113-00-8) + urea (57-13-6) → 2,4,6-triaminopyrimidine (1004-38-2) + 2-aminopyrimidine-4,6-diol (4425-67-6) + BARBITURIC ACID (67-52-7,944357-77-1) + 2,4,6-triamino-s-triazine (108-78-1,25778-04-5,94977-27-2) + pyrimidine-2,4,5-triamine (3546-50-7) + C4H4N2O3*C4H5N3O2 + 2,6-diaminopyrimidin-4-ol (56-06-4) + 4,6-diamino-2-hydroxypyrimidine (31458-45-4) + Malonamic acid (2345-56-4)

Guidance literature:

at 65 ℃; for 120h;

DOI:10.1002/cbic.202000510

upstream raw materials:

2,4,6-triaminopyrimidine

malonic acid

guanidine nitrate

urea

Refernces

• 1、 Menor Salván,Bouza, Marcos,Fialho, David M.,Burcar, Bradley T.,Fernández, Facundo M.,Hud, Nicholas V.. "Prebiotic Origin of Pre-RNA Building Blocks in a Urea “Warm Little Pond” Scenario". . p. 3504 - 3510. Retrieved 2020/10/02.