2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile)

Base Information Edit

Chemical Name:2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile)
CAS No.:120511-84-4
Molecular Formula:C15H17BrN2
Molecular Weight:305.217
Hs Code.:2926909090
UNII:OIS19A3U1G
DSSTox Substance ID:DTXSID30468018
Wikidata:Q72444786
Mol file:120511-84-4.mol

Synonyms:120511-84-4;2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile);3,5-bis(2-cyanoprop-2-yl)benzyl bromide;5-Bromomethyl anastrozole;OIS19A3U1G;2,2'-(5-BROMOMETHYL-1,3-PHENYLENE)-DI-(2-METHYLPROPIONITRILE);MFCD07782114;5-(Bromomethyl)-a,a,a',a'-tetramethyl-1,3-benzenediacetonitrile;2-[3-(bromomethyl)-5-(2-cyanopropan-2-yl)phenyl]-2-methylpropanenitrile;2,2-(5-(Bromomethyl)benzene-1,3-diyl)bis(2-methylpropanenitrile);C15H17BrN2;2,2'-[5-(Bromomethyl)-1,3-phenylene]bis(2-methylpropanenitrile);2-[3-(bromomethyl)-5-(1-cyano-1-methylethyl)phenyl]-2-methylpropanenitrile;Anastrozole Impurity IV;UNII-OIS19A3U1G;3,5-Bis(1-cyano-1-methylethyl)benzyl Bromide;Anastrozole impurity C [EP];AMY197;SCHEMBL2258695;5-Bromomethyl anastrozole [USP];DTXSID30468018;IHXHGCDOJLOZML-UHFFFAOYSA-N;BCP08812;2,2'-(5-BROMOMETHYL-1,3-PHENYLENE)DI(2-METHYLPROPIONONITRILE);AKOS015889686;AC-6804;3,5-bis(2-cyanoprop-2-yl)benzylbromide;DS-15010;SY028595;ANASTROZOLE IMPURITY C [EP IMPURITY];CS-0179353;FT-0642941;3,5-bis-(1-cyano-1-methylethyl)benzylbromide;F12198;3,5-bis(1-cyano-1-methylethyl) benzyl bromide;5-BROMOMETHYL ANASTROZOLE [USP IMPURITY];Q-100987;?,?,?',?'-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile;2,2'-(5-bromomethyl-1,3-phenylene)di(2-methylpropionitrile);a,a,a',a'-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile;2,2'-[5-(Bromomethyl)benzene-1,3-diyl]bis(2-methylpropanenitrile);5-Bromomethyl-alpha,alpha,alpha,alpha-tetramethyl-1,3-benzenediacetonitrile;2,2 inverted exclamation mark -[5-(Bromomethyl)-1,3-phenylene]bis(2-methylpropanenitrile);2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile) (Anastrozole Impurity);2-[3-(Bromomethyl)-5-(1-cyano-1-methylethyl)-phenyl]-2-methylpropanenitrile;alpha , alpha , alpha ', alpha '-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile;alpha,alpha,alpha',alpha'-tetramethyl-5-bromomethyl-1,3-benzene-diacetonitrile;5-(Bromomethyl)-|A inverted exclamation mark,|A inverted exclamation mark,|A inverted exclamation mark,|A inverted exclamation mark-tetramethyl-1,3-benzenediacetonitrile

Suppliers and Price of 2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile)

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
500mg
$ 700.00

TRC
α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
1g
$ 1165.00

TRC
α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
50mg
$ 95.00

Matrix Scientific
2-[3-(Bromomethyl)-5-(1-cyano-1-methylethyl)-phenyl]-2-methylpropanenitrile 97%
1g
$ 230.00

Crysdot
2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile) 95+%
10g
$ 297.00

Biosynth Carbosynth
a,a,a',a'-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
50 mg
$ 180.00

Biosynth Carbosynth
a,a,a',a'-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
100 mg
$ 270.00

Biosynth Carbosynth
a,a,a',a'-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
250 mg
$ 587.50

Biosynth Carbosynth
a,a,a',a'-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
500 mg
$ 1000.00

Biosynth Carbosynth
a,a,a',a'-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile
1 g
$ 1460.00

Total 143 raw suppliers

Chemical Property of 2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile) Edit

Chemical Property:

Appearance/Colour:Off-White Solid
Melting Point:98-100 ºC
Boiling Point:379.996 ºC at 760 mmHg
Flash Point:183.615 ºC
PSA：47.58000
Density:1.277 g/cm³
LogP:4.18386
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:304.05751
Heavy Atom Count:18
Complexity:357

Purity/Quality:

99% ^*data from raw suppliers

α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C#N)C1=CC(=CC(=C1)CBr)C(C)(C)C#N
Uses α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile (Anastrozole EP Impurity C) is an impurity of Anastrozole (A637425) (impurity D). α,α,α’,α’-Tetramethyl-5-bromomethyl-1,3-benzenediacetonitrile (Anastrozole EP Impurity C) is an impurity of Anastrozole(impurity D).

Technology Process of 2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile)

There total 2 articles about 2,2'-(5-(Bromomethyl)-1,3-phenylene)bis(2-methylpropanenitrile) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.4%

: 120511-72-0
3,5-bis(2-cyanoprop-2-yl)toluene

: 120511-84-4
2-[3-bromomethyl-5-(cyanodimethylmethyl)phenyl]-2-methylpropanenitrile

Guidance literature:: With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In dichloromethane; at 15 - 25 ℃; Reagent/catalyst; Solvent; Temperature;