Multi-step reaction with 8 steps
1.1: sodium / diethyl ether / 0 - 20 °C
2.1: water / 0.17 h / 20 °C
2.2: 2 h / Heating / reflux
2.3: pH 4
3.1: tetrabutylammomium bromide; phosphorus pentoxide / toluene / 5 h / Heating / reflux
4.1: ammonia / ethanol / 20 h / 130 °C
5.1: toluene / 3 h / Heating / reflux
6.1: acetic acid / 0.5 h / 140 °C
7.1: lithium hydroxide / 1,4-dioxane; water / 0.42 h / 20 - 60 °C
8.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 h / 20 °C
With
lithium hydroxide; tetrabutylammomium bromide; ammonia; sodium; phosphorus pentoxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; diethyl ether; ethanol; water; acetic acid; dimethyl sulfoxide; toluene;