(2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

Base Information Edit

Chemical Name:(2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
CAS No.:135042-12-5
Molecular Formula:C10H17NO5
Molecular Weight:231.249
Hs Code.:29339900
European Community (EC) Number:621-971-2
UNII:I467853HPL
DSSTox Substance ID:DTXSID50350921
Wikidata:Q27280398
Mol file:135042-12-5.mol

Synonyms:135042-12-5;N-Boc-cis-4-Hydroxy-D-proline;Boc-cis-4-Hydroxy-D-proline;(2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;(2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid;N-Boc-4-hydroxy-D-proline, cis-;I467853HPL;(4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-D-proline;MFCD02094407;(2R,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid;N-Boc-4-hydroxy-D-proline, (4R)-(+)-;(2R,4R)-1-tert-butoxycarbonyl-4-hydroxy-pyrrolidine-2-carboxylic acid;1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)-;Boc-D-cis-Hyp-OH;Rel-(2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2R-cis)-;1218998-83-4;(2R,4R)-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid;SCHEMBL55611;cis-Boc-4-hydroxy-D-proline;N-Boc-cs-4-hydroxy-d-prolne;UNII-I467853HPL;(2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylicacid;cis-N-boc-4-hydroxy-D-proline;(2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecarboxylic acid;DTXSID50350921;BENKAPCDIOILGV-RNFRBKRXSA-N;AKOS015836482;CS-W002887;HY-W002887;N-Boc-cis-4-hydroxy-D-proline, 97%;N-T-BOC-CIS-4-HYDROXY-D-PROLINE;AC-24044;AS-19532;A2881;AM20080250;B5886;cis-4-hydroxy-n-tert-butoxycarbonyl-d-proline;EN300-158256;cis-N-(tert-Butoxycarbonyl)-4-hydroxy-D-proline;J-523513;Q27280398;Z1250093185;(4R)-1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-hydroxy-D-proline;(2R,4R)-4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;(2R,4R)4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;(R,R)-4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

Suppliers and Price of (2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-Boc-cis-4-hydroxy-d-proline
5g
$ 337.00

TRC
(2R,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylicAcid1-(1,1-Dimethylethyl)Ester
25g
$ 360.00

TRC
(2R,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylicAcid1-(1,1-Dimethylethyl)Ester
2.5g
$ 75.00

TRC
(2R,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylicAcid1-(1,1-Dimethylethyl)Ester
250mg
$ 50.00

TCI Chemical
cis-N-(tert-Butoxycarbonyl)-4-hydroxy-D-proline
5G
$ 114.00

TCI Chemical
cis-N-(tert-Butoxycarbonyl)-4-hydroxy-D-proline
1G
$ 40.00

SynQuest Laboratories
N-Boc-cis-4-hydroxy-D-proline 98%
1 g
$ 20.00

SynQuest Laboratories
N-Boc-cis-4-hydroxy-D-proline 98%
5 g
$ 68.00

Sigma-Aldrich
N-Boc-cis-4-hydroxy-D-proline 97%
1g
$ 49.00

Matrix Scientific
Boc-cis-4-hydroxy-D-proline
5g
$ 42.00

Total 67 raw suppliers

Chemical Property of (2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid Edit

Chemical Property:

Vapor Pressure:9.99E-08mmHg at 25°C
Melting Point:145 °C
Refractive Index:1.531
Boiling Point:390.9 °C at 760 mmHg
PKA:3.80±0.40(Predicted)
Flash Point:190.2 °C
Density:1.312 g/cm³
Storage Temp.:2-8°C
XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:231.11067264
Heavy Atom Count:16
Complexity:296

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Boc-cis-4-hydroxy-d-proline ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC(CC1C(=O)O)O
Isomeric SMILES:CC(C)(C)OC(=O)N1C[C@@H](C[C@@H]1C(=O)O)O
Uses N-Boc-cis-4-hydroxy-D-proline can be used:As a starting material in the synthesis of DNA mimicking pyrrolidine peptide nucleic acid (PNA) analog.In the synthesis of biologically important macrocyclic dilactones.As an intermediate in the synthesis of histamine H3?receptor antagonists.

Technology Process of (2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

There total 18 articles about (2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 2584-71-6,30724-02-8
cis-hydroxy-D-proline

: 135042-12-5,946610-68-0
(4R)-1-(tert-butoxycarbonyl)-4-hydroxy-D-proline

Guidance literature:: di-tert-butyl dicarbonate; cis-hydroxy-D-proline; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃;

With hydrogenchloride; In water;