5-Bromo-2-chloropyrimidine

Base Information

• Chemical Name: 5-Bromo-2-chloropyrimidine
• CAS No.: 32779-36-5
• Molecular Formula: C4H2BrClN2
• Molecular Weight: 193.43
• Hs Code.: 29335990
• Mol file: 32779-36-5.mol

Synonyms:5-bromo-2-chloro-pyrimidine;Pyrimidine, 5-bromo-2-chloro-;2-chloro-5-bromopyrimidine;

Chemical Property of 5-Bromo-2-chloropyrimidine

Chemical Property:

• Appearance/Colour: off-white to beige crystalline powder
• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 76-81 °C(lit.)
• Refractive Index: 1.588
• Boiling Point: 291.552 °C at 760 mmHg
• PKA: -2.84±0.22(Predicted)
• Flash Point: 130.126 °C
• PSA: 25.78000
• Density: 1.86 g/cm³
• LogP: 1.89250
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• Water Solubility.: insoluble

Purity/Quality:

HPLC>98.5% ^*data from raw suppliers

5-Bromo-2-chloropyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/39-37/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Bromo-2-chloropyrimidine is a intermediate in the synthesis of pharmaceutical goods such as inhibitors. It is applied as a pharmaceutical intermediate, in the synthesis of pharmaceutical goods such as inhibitors. It is also employed in the cross-coupling reactions of indium organometallics with 2,5-dihalopyrimidines.

Technology Process of 5-Bromo-2-chloropyrimidine

There total 8 articles about 5-Bromo-2-chloropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-bromopyrimidin-2-ol (38353-06-9,214290-49-0) → 5-Bromo-2-chloropyrimidine (32779-36-5)

Guidance literature:

With trichlorophosphate; at 80 ℃;

DOI:10.1002/jhet.5570450420

Reference yield: 84.0%

5-bromo-1H-pyrimidin-2-one (38353-06-9) → 5-Bromo-2-chloropyrimidine (32779-36-5)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; for 6h; Heating / reflux;

Reference yield: 80.0%

5-bromopyrimidine (4595-59-9) → 5-Bromo-2-chloropyrimidine (32779-36-5)

Guidance literature:

With trichlorophosphate; at 0 - 120 ℃; for 4.16667h;

upstream raw materials:

5-bromopyrimidin-2-ol

5-bromo-1H-pyrimidin-2-one

5-bromo-2-aminopyrimidine

5-bromopyrimidine

Downstream raw materials:

5H-[1]-chromeno[2,3-b]pyridine

5-Bromo-2-(2-methylphenoxy)pyrimidine

5-bromo-2-(1-methyl-2-propenyloxy)pyrimidine

4-(5-Bromo-pyrimidin-2-yloxy)-3-fluoro-phenylamine

Refernces

• 1、 -. "Preparation method for 2-chloro-5-(piperidin-4-yl)pyrimidine". Paragraph 0020; 0021; 0022. . Retrieved 2018/04/02.
• 2、 -. "Method for preparing 2-chloropyrimidine derivative". Paragraph 0021; 0022. . Retrieved 2017/12/27.