Cyclopropylacetic acid

Base Information

• Chemical Name: Cyclopropylacetic acid
• CAS No.: 5239-82-7
• Molecular Formula: C5H8O2
• Molecular Weight: 100.117
• Hs Code.: 29162000
• Mol file: 5239-82-7.mol

Synonyms:2-Cyclopropaneaceticacid;2-Cyclopropylacetic acid;

Chemical Property of Cyclopropylacetic acid

Chemical Property:

• Vapor Pressure: 0.00177mmHg at 25°C
• Refractive Index: 1.4350
• Boiling Point: 191.7 °C at 760 mmHg
• PKA: 4.76±0.10(Predicted)
• Flash Point: 93.8 °C
• PSA: 37.30000
• Density: 1.171 g/cm³
• LogP: 0.87110
• Storage Temp.: Store below +30°C.
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%, ^*data from raw suppliers

Cyclopropylacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-41-37/38-22
• Safety Statements: 26-36/37/39-45-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Cyclopropylacetic Acid is used in the synthesis of many organic compounds. Such compounds include Cyproconazole which is an agricultural fungicide and also in synthesis of potent nicotinic acid receptor agonists used in treatment of Dyslipidemia.

Technology Process of Cyclopropylacetic acid

There total 19 articles about Cyclopropylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

cyclopropyl-malonic acid (5617-88-9) → cyclopropylacetic acid (5239-82-7)

Guidance literature:

at 160 ℃;

Reference yield: 96.0%

2-cyclopropylacetonitrile (6542-60-5) → cyclopropylacetic acid (5239-82-7)

Guidance literature:

With water; potassium hydroxide; In ethanol; at 90 ℃; for 18h;

DOI:10.1002/ejoc.202001532

Reference yield: 75.0%

diiodomethane (75-11-6) + but-3-enoic acid (625-38-7) → cyclopropylacetic acid (5239-82-7)

Guidance literature:

With diethylzinc; In toluene; Ambient temperature;

DOI:10.1021/jo00251a015

upstream raw materials:

diazomethane

cyclopropanecarboxylic acid chloride

2-cyclopropylacetonitrile

2-cyclopropylacetaldehyde

Downstream raw materials:

1-butylene

trans-2-Butene

2-cyclopropyl-N-methoxy-N-methyl-acetamide

2-cyclopropyl-N-[2-(5-methyl-3-phenyl-isoxazol-4-yl)-imidazo[1,2-a]pyridin-6-yl]-acetamide

Refernces

• 1、 Christoffers, Jens,Speldrich, Jean-Marico. "Mechanistic Insights into the Formation of δ-Lactones by Cerium-Catalyzed Aerobic Coupling of β-Oxoesters with Enol Acetates". . p. 907 - 914. Retrieved 2021/01/18.
• 2、 -. "Cyclopropylacetic acid production method". Paragraph 0019; 0022. . Retrieved 2019/10/01.