4′-O-benzylapigenin

Base Information

• Chemical Name: 4′-O-benzylapigenin
• CAS No.: 52309-82-7
• Molecular Formula: C₂₂H₁₆O₅
• Molecular Weight: 360.366
• Mol file: 52309-82-7.mol

Synonyms:4′-O-benzylapigenin

Chemical Property of 4′-O-benzylapigenin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4′-O-benzylapigenin

There total 8 articles about 4′-O-benzylapigenin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C34H36O14 → 4′-O-benzylapigenin (52309-82-7)

Guidance literature:

With sulfuric acid; In ethanol; for 2h; Reflux;

DOI:10.1016/j.carres.2012.05.013

Reference yield:

naringin (10236-47-2) → 4′-O-benzylapigenin (52309-82-7)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; iodine / 2 h / 95 °C

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 90 °C / Inert atmosphere

3: sulfuric acid / ethanol / 2 h / Reflux

With pyridine; sulfuric acid; iodine; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.carres.2012.05.013

Reference yield:

apigenin 7-O-neohesperidoside → 4′-O-benzylapigenin (52309-82-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 90 °C / Inert atmosphere

2: sulfuric acid / ethanol / 2 h / Reflux

With sulfuric acid; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.carres.2012.05.013

upstream raw materials:

2,4,6-trihydroxyacetophenone

p-(benzyloxy)benzoic acid anhydride

Ethyl 4-hydroxybenzoate

p-(benzyloxy)benzoic acid

Downstream raw materials:

4'-O-benzylapigenin-7-O-β-D-tetra-O-acetylglucoside

4'-O-benzylapigenin-7-O-β-D-tetra-O-acetylgalactoside

7-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)apigenin

apigenin 7-O-glucoside

Refernces