2-Pyridinepropanol

Base Information

• Chemical Name: 2-Pyridinepropanol
• CAS No.: 2859-68-9
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 2933399090
• European Community (EC) Number: 220-676-2
• NSC Number: 2243
• UNII: 5GHN91K70Q
• DSSTox Substance ID: DTXSID6062672
• Nikkaji Number: J208.846K
• Wikidata: Q27262122
• ChEMBL ID: CHEMBL3229430
• Mol file: 2859-68-9.mol

Synonyms:1-(alpha-pyridine)-2-propanol;PGR-1

Chemical Property of 2-Pyridinepropanol

Chemical Property:

• Vapor Pressure: 0.00631mmHg at 25°C
• Melting Point: 34°C
• Refractive Index: n20/D 1.5295(lit.)
• Boiling Point: 260.2 ºC at 760 mmHg
• PKA: 14.92±0.10(Predicted)
• Flash Point: 103.8 ºC
• PSA: 33.12000
• Density: 1.059 g/cm³
• LogP: 1.00650
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 85.3

Purity/Quality:

99% ^*data from raw suppliers

2-Pyridinepropanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Pyridines
• Canonical SMILES: C1=CC=NC(=C1)CCCO
• Uses: 3-Pyridin-2-ylpropan-1-ol is a reagent in the synthesis of pyridylalcohols that exhibits hypoglycemic activity in fasted rats.

Technology Process of 2-Pyridinepropanol

There total 20 articles about 2-Pyridinepropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-(pyridin-2-yl)prop-2-yn-1-ol (29768-03-4) → 3-(pyridin-2-yl)-propanol (2859-68-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; at 24 - 28 ℃; for 6h;

DOI:10.1002/ejoc.202000695

Reference yield: 92.0%

3-(4-bromopyridin-2-yl)prop-2-yn-1-ol → 3-(pyridin-2-yl)-propanol (2859-68-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 1h; under 760.051 Torr;

DOI:10.1021/acs.orglett.9b01397

Reference yield: 82.0%

ethyl 3-(2-pyridinyl)propanoate (2739-74-4) → 3-(pyridin-2-yl)-propanol (2859-68-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1002/hlca.19820650621

upstream raw materials:

α-picoline

2-chloro-ethanol

ethyl 3-(2-pyridinyl)propanoate

2-(5-bromopyridin-2-yl)-prop-2-yn-1-ol

Downstream raw materials:

N-phenyl-3-(2-pyridyl)propyl carbamate

1-(4-fluoro-phenacyl)-2-(3-hydroxy-propyl)-pyridinium; bromide

3-(pyridin-2-yl)propanoic acid

indolizidine

Refernces

• 1、 Jo, Young-In,Burke, Martin D.,Cheon, Cheol-Hong. "Modular Syntheses of Phenanthroindolizidine Natural Products". supporting information. p. 4201 - 4204. Retrieved 2019/06/14.
• 2、 Call, Arnau,Casadevall, Carla,Acu?a-Parés, Ferran,Casitas, Alicia,Lloret-Fillol, Julio. "Dual cobalt-copper light-driven catalytic reduction of aldehydes and aromatic ketones in aqueous media". . p. 4739 - 4749. Retrieved 2017/07/10.