[2-[(2-Methylpropan-2-yl)oxy]-2-oxoethyl]azanium;chloride

Base Information

• Chemical Name: [2-[(2-Methylpropan-2-yl)oxy]-2-oxoethyl]azanium;chloride
• CAS No.: 27532-96-3
• Molecular Formula: C6H13NO2^.HCl
• Molecular Weight: 167.636
• Hs Code.: 29224995
• Mol file: 27532-96-3.mol

Synonyms:SCHEMBL14125854;AKOS023093348

Chemical Property of [2-[(2-Methylpropan-2-yl)oxy]-2-oxoethyl]azanium;chloride

Chemical Property:

• Appearance/Colour: Crystalline
• Vapor Pressure: 0.026mmHg at 25°C
• Melting Point: 141-143 °C(lit.)
• Refractive Index: 1.522
• Boiling Point: 145.7 °C at 760 mmHg
• Flash Point: 20.7 °C
• PSA: 52.32000
• Density: 0.973 g/cm³
• LogP: 1.78910
• Storage Temp.: −20°C
• Solubility.: H2O: 0.1 g/mL, clear, colorless
• Water Solubility.: Soluble in methanol and water
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 167.0713064
• Heavy Atom Count: 10
• Complexity: 104

Purity/Quality:

98% ^*data from raw suppliers

Glycine, t-Butyl Ester, Hydrochloride ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)C[NH3+].[Cl-]
• Uses: Glycine tert butyl ester hydrochloride is a substituted Glycine (G615990) used as parakeratosis inhibitor and external composition for skin. Glycine t-butyl ester hydrochloride is a substituted Glycine used as parakeratosis inhibitor.

Technology Process of [2-[(2-Methylpropan-2-yl)oxy]-2-oxoethyl]azanium;chloride

There total 1 articles about [2-[(2-Methylpropan-2-yl)oxy]-2-oxoethyl]azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ tert-butylisocyanoacetate + glycine tert-butyl ester hydrochloride (27532-96-3)

Guidance literature:

Reference yield: 100.0%

glycine tert-butyl ester hydrochloride (27532-96-3) + 2-Nitrobenzenesulfonyl chloride (1694-92-4) → tert-butyl 2-[(2-nitrobenzene)sulfonamido]acetate (552847-32-2)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

DOI:10.1016/j.tet.2018.06.056

Reference yield: 99.0%

N-Fmoc L-Phe (35661-40-6) + glycine tert-butyl ester hydrochloride (27532-96-3) → Fmoc-L-Phe-Gly-OtBu

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 4h;

Downstream raw materials:

carbobenzoxy-L-asparaginylglycine tert-butyl ester

hippuric acid tert-butyl ester

N-(diphenylmethylene)glycine tert-butyl ester

N-cyclohexyl-N-methyl-4-<<2-amino-3-<(tert-butyloxycarbonyl)methyl>-3,4-dihydroquinazolin-6-yl>oxy>butyramide hydrobromide

Refernces