2-Chloro-N,N-bis(2-methylpropyl)acetamide

Base Information

• Chemical Name: 2-Chloro-N,N-bis(2-methylpropyl)acetamide
• CAS No.: 5326-82-9
• Molecular Formula: C10H20ClNO
• Molecular Weight: 205.728
• Hs Code.: 2924199090
• Mol file: 5326-82-9.mol

Synonyms:Acetamide, 2-chloro-N,N-bis(2-methylpropyl)-;2-Chloro-N,N-diisobutylacetamide;N,N-Diisobutyl-2-chloroacetamide;N,N-Diisobutylchloroacetamide;NSC 4075;Chembrdg-bb 4024655;

Chemical Property of 2-Chloro-N,N-bis(2-methylpropyl)acetamide

Chemical Property:

• Vapor Pressure: 0.0079mmHg at 25°C
• Refractive Index: 1.453
• Boiling Point: 268 °C at 760 mmHg
• PKA: -0.95±0.70(Predicted)
• Flash Point: 115.9 °C
• PSA: 20.31000
• Density: 0.979 g/cm³
• LogP: 2.36580
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N,N-diisobutylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-N,N-bis(2-methylpropyl)acetamide

There total 1 articles about 2-Chloro-N,N-bis(2-methylpropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

diisobutylamine (110-96-3) + chloroacetyl chloride (79-04-9) → N,N-di-isobutylcarbamoyl methyl chloride (5326-82-9)

Guidance literature:

With triethylamine; In diethyl ether; at 20 ℃; for 8h;

DOI:10.1021/jo8002166

Reference yield: 81.0%

3,4-dimercaptotoluene (496-74-2) + N,N-di-isobutylcarbamoyl methyl chloride (5326-82-9) → C27H46N2O2S2 (1609277-45-3)

Guidance literature:

3,4-dimercaptotoluene; With sodium hydroxide; In methanol; for 0.5h;

N,N-di-isobutylcarbamoyl methyl chloride; In methanol; for 3h;

DOI:10.1016/j.poly.2014.03.015

Reference yield: 70.0%

N,N-di-isobutylcarbamoyl methyl chloride (5326-82-9) + 4,4’-di-tert-butyldiphenylphosphine oxide (326921-37-3) → bis(4-tert-butylphenyl)-[(N,N-di-isobutylcarbamoyl)methyl]phosphine oxide

Guidance literature:

In tetrahydrofuran; for 3h; Heating;

upstream raw materials:

diisobutylamine

chloroacetyl chloride

Downstream raw materials:

<3-Hydroxy-propyl>---amin

2-(diisobutylaminoxy)ethyl 3-chlorobenzoate

C₂₇H₄₆N₂O₂S₂

Refernces

• 1、 Sharma, Shikha,Ghosh, Sunil K.,Anitha,Sharma, Joti N.. "α-Dialkylamino N,N-diisobutylacetamides: A new class of anion exchanger with intramolecular buffering properties". . p. 27837 - 27842. Retrieved 2014.
• 2、 Bernier, David,Blake, Alexander J.,Woodward, Simon. "Improved procedure for the synthesis of enamine N-oxides". . p. 4229 - 4232. Retrieved 2008/09/20.