Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

Base Information

• Chemical Name: Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide
• CAS No.: 75980-60-8
• Deprecated CAS: 596818-40-5,1266684-52-9,1004988-40-2,1629246-19-0,743458-22-2
• Molecular Formula: C22H21O2P
• Molecular Weight: 348.381
• Hs Code.: 29319090
• European Community (EC) Number: 278-355-8
• UNII: B9EIM2D97X
• DSSTox Substance ID: DTXSID4052502
• Nikkaji Number: J240.339K
• Wikidata: Q27274548
• ChEMBL ID: CHEMBL3561198
• Mol file: 75980-60-8.mol

Synonyms:(2,4,6-trimethylbenzoyl) diphenylphosphine oxide;2,4,6-trimethylbenzoyldiphenylphosphine oxide;Lucirin TPO;TMBDPO cpd

Chemical Property of Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

Chemical Property:

• Appearance/Colour: white or cream powder
• Vapor Pressure: 6.71E-11mmHg at 25°C
• Melting Point: 88-92 °C
• Refractive Index: n20/D 1.475(lit.)
• Boiling Point: 519.6 °C at 760 mmHg
• Flash Point: 268.1 °C
• PSA: 43.95000
• Density: 1.17 g/cm³
• LogP: 4.76610
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• Water Solubility.: 3.4mg/L at 20℃
• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 348.12791691
• Heavy Atom Count: 25
• Complexity: 468

Purity/Quality:

99%, ^*data from raw suppliers

Diphenyl(2,4,6-trimethylbenzoyl)phosphine Oxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,N
• Statements: 22-62-51/53
• Safety Statements: 22-24/25-61-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)C)C(=O)P(=O)(C2=CC=CC=C2)C3=CC=CC=C3)C
• Recent ClinicalTrials: Evaluating the Efficacy and Safety of Different Human Thrombopoietin (rhTPO) Regimens in the Treatment of Patients With Primary Immune Thrombocytopenia (ITP)
• Uses: Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide is a photo initiator, used in many kinds of ink industries TPO can be used in the photo-crosslinking of PMMA composite, which can further be used as a gate insulator in organic thin film transistors (OTFTs). It can also be used in the formation of UV curable urethane-acrylate coatings. It may also be used in the photoinduced reaction for the formation of organophosphine compounds, which potentially find their usage as ligands with metal catalysts and reagents.

Technology Process of Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

There total 52 articles about Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

mesytaldehyde (487-68-3) + Diphenylphosphine oxide (4559-70-0) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Guidance literature:

mesytaldehyde; Diphenylphosphine oxide; In dichloromethane; for 6h; Green chemistry;

With ammonium metavanadate; dihydrogen peroxide; at 8 - 20 ℃; for 5.5h; Reagent/catalyst; Green chemistry;

Reference yield: 95.6%

(sec-butyloxy)di(phenyl)phosphine (65119-90-6) + mesitylene-2-carboxylic acid chloride (938-18-1) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Guidance literature:

at 50 - 90 ℃; for 7.33333h;

Reference yield: 95.1%

diphenyl n-propoxyphosphine (92556-46-2) + mesitylene-2-carboxylic acid chloride (938-18-1) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Guidance literature:

at 50 - 90 ℃; for 7.33333h;

upstream raw materials:

Ethyl diphenylphosphinite

mesitylene-2-carboxylic acid chloride

1,3,5-trimethyl-benzene

(trichloromethyl)mesitylene

Downstream raw materials:

mesytaldehyde

mesitylenecarboxylic acid

diphenyl-phosphinic acid

Diphenylphosphine oxide

Refernces

• 1、 -. "Preparation method of methyl substituted benzaldehyde". . . Retrieved 2021/03/06.
• 2、 Chen, Xingyu,Liu, Xiaoyan,Zhu, Hong,Wang, Zhiqian. "Palladium-catalyzed C–P bond activation of aroyl phosphine oxides without the adjacent “anchoring atom”". . . Retrieved 2021/01/14.