2-Chloroethylamine hydrochloride

Base Information

• Chemical Name: 2-Chloroethylamine hydrochloride
• CAS No.: 870-24-6
• Molecular Formula: C2H7Cl2N
• Molecular Weight: 115.99
• Hs Code.: 29211980
• European Community (EC) Number: 212-793-2
• NSC Number: 10871
• UNII: 8040U3I02T
• DSSTox Substance ID: DTXSID60878686
• Wikidata: Q27269111
• ChEMBL ID: CHEMBL540550
• Mol file: 870-24-6.mol

Synonyms:2-chloroethylamine;2-chloroethylamine hydrochloride;2-chloroethylamine monohydrochloride;ethanamine, 2-chloro-, hydrochloride (1:1)

Chemical Property of 2-Chloroethylamine hydrochloride

Chemical Property:

• Appearance/Colour: white to light beige crystalline powder
• Vapor Pressure: 25.3mmHg at 25°C
• Melting Point: 140-150 °C(lit.)
• Refractive Index: 1.427
• Boiling Point: 108.9 °C at 760 mmHg
• Flash Point: 19.7 °C
• PSA: 26.02000
• Density: 1.038 g/cm3
• LogP: 1.68620
• Storage Temp.: Store below +30°C.
• Sensitive.: Hygroscopic
• Solubility.: 5666g/l
• Water Solubility.: SOLUBLE
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 114.9955546
• Heavy Atom Count: 5
• Complexity: 10

Purity/Quality:

99% ^*data from raw suppliers

2-Chloroethylamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,C
• Statements: 36/37/38-68-34
• Safety Statements: 26-36-37/39-45-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CCl)N.Cl
• Uses: 2-chloroethylamine hydrochloride is used as an intermediate in active pharmaceutical ingredients and dyes. It is also used in organic synthesis. Further, it is employed as a derivatizing reagent for amino acids, dipeptides and nucleotides. 2-Chloroethylamine hydrochloride can be used in the preparation of novel Schiff base ligands. These ligands, when immobilized on silica gels, form inexpensive materials for the removal of metal ions such as Ni2+ and Co2+ ions from contaminated water. Other applications:Alginate derivatization via aminoethylation to form aminoethyl alginate.Synthesis of N-(2-chloroethyl)-benzaldimine.Derivatization of starch to form aminoethyl (AE-St) starch derivatives.

Technology Process of 2-Chloroethylamine hydrochloride

There total 10 articles about 2-Chloroethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-amino-ethanol hydrochloride (2002-24-6) → 2-chloroethanamine hydrochloride (870-24-6)

Guidance literature:

With thionyl chloride; In chloroform; for 5h; Heating;

Reference yield: 97.0%

thionyl chloride (7719-09-7) + 2-amino-ethanol hydrochloride (2002-24-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-chloroethanamine hydrochloride (870-24-6)

Guidance literature:

In benzene;

Reference yield: 92.2%

ethanolamine (141-43-5) → 2-chloroethanamine hydrochloride (870-24-6)

Guidance literature:

ethanolamine; With hydrogenchloride; sodium hydroxide; In water; at 20 ℃; for 0.75h;

With hydrogenchloride; Adipic acid; In water; at 120 ℃; for 4h; Temperature; Reagent/catalyst;

upstream raw materials:

ethyleneimine

N-(2-Hydroxyethyl)phthalimide

2-amino-ethanol hydrochloride

ethanolamine

Downstream raw materials:

N-(2-chloroethyl)-4-nitrobenzamide

2-Chloroethyl isothiocyanate

N-(2-chloro-ethyl)-N'-nitro-guanidine

4,5-dihydro-oxazol-2-ylamine

Refernces

• 1、 -. "Novel synthesis method of Istaroxime". Paragraph 0111; 0112; 0113; 0114. . Retrieved 2016/10/10.
• 2、 Sinha, Girish Kumar,Mehra,Kumar, Sharad. "Synthesis of some nitrogen mustards (Mannich bases)". experimental part. p. 1261 - 1264. Retrieved 2012/04/04.