5-CHLORO-7-METHYLISATIN

Base Information

• Chemical Name: 5-CHLORO-7-METHYLISATIN
• CAS No.: 14389-06-1
• Molecular Formula: C9H6ClNO2
• Molecular Weight: 195.605
• Hs Code.: 2933990090
• Mol file: 14389-06-1.mol

Synonyms:Indole-2,3-dione,5-chloro-7-methyl- (7CI,8CI);5-Chloro-7-methyl-1H-indole-2,3-dione;5-Chloro-7-methylisatin;

Chemical Property of 5-CHLORO-7-METHYLISATIN

Chemical Property:

• Melting Point: 283°C (dec.)
• Refractive Index: 1.611
• Boiling Point: 259.319 °C at 760 mmHg
• PKA: 8.67±0.20(Predicted)
• Flash Point: 110.632 °C
• PSA: 46.17000
• Density: 1.494 g/cm³
• LogP: 1.92120
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

5-Chloro-7-methylindoline-2,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36-52
• Safety Statements: 22-24/25-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-CHLORO-7-METHYLISATIN

There total 6 articles about 5-CHLORO-7-METHYLISATIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

7-methyl-1H-indole-2,3-dione (1127-59-9) → 5-chloro-7-methyl-1H-indole-2,3-dione (14389-06-1)

Guidance literature:

With sulfur dioxide; chlorine; at 20 - 65 ℃; for 2h; Reagent/catalyst; Temperature; regioselective reaction;

Reference yield:

N-(4-chloro-2-methylphenyl)-2-(hydroxyimino)acetamide (13208-93-0) → 5-chloro-7-methyl-1H-indole-2,3-dione (14389-06-1)

Guidance literature:

With sulfuric acid; at 80 ℃;

DOI:10.1016/S0960-894X(02)00377-3

Reference yield:

hydroxyimino-acetic acid-(4-chloro-2-methyl-anilide) (13208-93-0) → 5-chloro-7-methyl-1H-indole-2,3-dione (14389-06-1)

Guidance literature:

With sulfuric acid; at 80 - 95 ℃; Verduennen der Reaktionsfluessigkeit mit Wasser;

upstream raw materials:

hydroxyimino-acetic acid-(4-chloro-2-methyl-anilide)

N-(4-chloro-2-methylphenyl)-2-(hydroxyimino)acetamide

4-chloro-2-methylbenzeneamine

7-methyl-1H-indole-2,3-dione

Downstream raw materials:

2-amino-3-methyl-5-chlorobenzoyl-N-methylamine

C₁₆H₁₂ClNO₂

C₁₈H₁₃ClN₄O₃S

N-(3-{1-[5-chloro-1-(2-methoxyethyl)-7-methyl-1H-indole-3-carbonyl]piperidin-4-yl}-4-fluorobenzyl)-2,2,2-trifluoroacetamide

Refernces

• 1、 -. "AN EFFICIENT NEW PROCESS FOR SYNTHESIS OF 2-AMINO-5-CHLORO-N-,3-DIMETHYLBENZAMIDE". Paragraph 0314-0315. . Retrieved 2021/05/07.
• 2、 Silva, Ba?rbara V.,Esteves, Pierre M.,Pinto, Angelo C.. "Chlorination of isatins with trichloroisocyanuric acid". scheme or table. p. 257 - 263. Retrieved 2011/10/01.