2-Chloro-N-(hydroxymethyl)acetamide

Base Information

• Chemical Name: 2-Chloro-N-(hydroxymethyl)acetamide
• CAS No.: 2832-19-1
• Molecular Formula: C3H6ClNO2
• Molecular Weight: 123.539
• Hs Code.: 29241990
• European Community (EC) Number: 220-598-9
• NSC Number: 9963
• UNII: 20J873AX6G
• DSSTox Substance ID: DTXSID2041412
• Nikkaji Number: J7.919G
• Wikidata: Q27253470
• ChEMBL ID: CHEMBL3184823
• Mol file: 2832-19-1.mol

Synonyms:chloractamide-N-metholol;N-methylol-chloracetamide

Chemical Property of 2-Chloro-N-(hydroxymethyl)acetamide

Chemical Property:

• Appearance/Colour: White or almost white crystalline powder
• Vapor Pressure: 4.02E-07mmHg at 25°C
• Melting Point: 100-105 °C(lit.)
• Refractive Index: 1.47
• Boiling Point: 374 °C at 760 mmHg
• PKA: 12.63±0.46(Predicted)
• Flash Point: 180 °C
• PSA: 49.33000
• Density: 1.33 g/cm³
• LogP: -0.31790
• Storage Temp.: 0-6°C
• Sensitive.: Hygroscopic
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Very soluble in water. Poorly soluble in aliphatic hydrocarbons.
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 123.0087061
• Heavy Atom Count: 7
• Complexity: 66

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N-(hydroxymethyl)acetamide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-43-40-20/21/22
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Uses -> Biocides/Disinfectants
• Canonical SMILES: C(C(=O)NCO)Cl
• Uses: N-Methylolchloro-acetamide is a preservative in cooling fluids and cosmetics. An organic building block. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals. As dyestuff intermediate . 2-Chloro-N-(hydroxymethyl)acetamide (N-hydroxymethylchloroacetamide) may be used as a reagent in the synthesis of 1-(aminomethyl)-2-methoxynaphthalene hydrochloride and as a amidomethylating reagent for N,N-dialkylanilines (Tscherniac-Einhorn reaction).

Technology Process of 2-Chloro-N-(hydroxymethyl)acetamide

There total 2 articles about 2-Chloro-N-(hydroxymethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Chloroacetamide (79-07-2) → 2-Chloro-N-(hydroxymethyl)acetamide (2832-19-1)

Guidance literature:

With hydrogenchloride;

Reference yield:

→ 2-Chloro-N-(hydroxymethyl)acetamide (2832-19-1)

Guidance literature:

Reference yield: 76.4%

2-Chloro-N-(hydroxymethyl)acetamide (2832-19-1) + 2-(methylthio)-4-(1,1-dimethylethyl)phenol (64096-97-5) → 2-aminomethyl-4-(1,1-dimethylethyl)-6-(methylthio)phenol hydrochloride (61626-89-9)

Guidance literature:

With hydrogenchloride; sulfuric acid; In ethanol; acetic acid;

upstream raw materials:

formaldehyd

Chloroacetamide

Downstream raw materials:

{4-[(2-chloro-acetylamino)-methyl]-phenyl}-acetic acid

4-(N-Chloroacetylamino)methyl-2-thiophene carboxylic acid

5-[(chloroacetyl-amino)-methyl]-furan-2-carboxylic acid methyl ester

chloro-acetic acid-(2-hydroxy-5-nitro-benzylamide)

Refernces

• 1、 -. "Synergistic biocidal composition". . . Retrieved 2008/06/13.
• 2、 -. "3-NITROISOXAZOLES AND THEIR USE IN THE PROTECTION OF MATERIALS". . . Retrieved 2012/09/11.