Technology Process of 4aβ,8-dimethyl-3,4,4a,5,6,8aα-hexahydro-2<1H>-naphthalenone
There total 1 articles about 4aβ,8-dimethyl-3,4,4a,5,6,8aα-hexahydro-2<1H>-naphthalenone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: (i) OsO4, Py, (ii) NaIO4
2: POCl3, Py
With
pyridine; trichlorophosphate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) DABCO, sodium sulfate; 2.) sodium borohydride / 1.) THF, r.t., 48 h; 2.) ethanol, 0 deg C, 2 h
2: 88 percent / sodium borohydride / ethanol / 10 h / Ambient temperature
3: 11 mg / dicyclohexylcarbodiimide, copper(I) chloride / diethyl ether / 8.5 h / Heating
4: 59 percent / diisobutylaluminum hydride / toluene / 3 h / -78 °C
With
1,4-diaza-bicyclo[2.2.2]octane; sodium tetrahydroborate; diisobutylaluminium hydride; sodium sulfate; dicyclohexyl-carbodiimide; copper(l) chloride;
In
diethyl ether; ethanol; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) DABCO, sodium sulfate; 2.) sodium borohydride / 1.) THF, r.t., 48 h; 2.) ethanol, 0 deg C, 2 h
2: 88 percent / sodium borohydride / ethanol / 10 h / Ambient temperature
3: 7 mg / dicyclohexylcarbodiimide, copper(I) chloride / diethyl ether / 8.5 h / Heating
4: 60 percent / diisobutylaluminum hydride / toluene / 3 h / -78 °C
With
1,4-diaza-bicyclo[2.2.2]octane; sodium tetrahydroborate; diisobutylaluminium hydride; sodium sulfate; dicyclohexyl-carbodiimide; copper(l) chloride;
In
diethyl ether; ethanol; toluene;