N-Boc-L-phenylalaninol

Base Information Edit

Chemical Name:N-Boc-L-phenylalaninol
CAS No.:66605-57-0
Molecular Formula:C14H21NO3
Molecular Weight:251.326
Hs Code.:29242990
DSSTox Substance ID:DTXSID20369969
Nikkaji Number:J834.472H
Wikidata:Q72450271
Mol file:66605-57-0.mol

Synonyms:66605-57-0;N-Boc-L-phenylalaninol;Boc-L-phenylalaninol;Boc-Phenylalaninol;N-(tert-Butoxycarbonyl)-L-phenylalaninol;(S)-2-(Boc-amino)-3-phenyl-1-propanol;tert-butyl N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]carbamate;(S)-tert-butyl 1-hydroxy-3-phenylpropan-2-ylcarbamate;(S)-tert-Butyl (1-hydroxy-3-phenylpropan-2-yl)carbamate;(S)-(-)-2-(tert-Butoxycarbonylamino)-3-phenyl-1-propanol;(S)-N-(TERT-BUTOXYCARBONYL)-PHENYLALANINOL;(S)-N-(tert-Butoxycarbonyl)-beta-phenylalaninol;Boc-Phe-ol;MFCD00076976;Boc-PheCH2OH;N-Boc-Phenylalaninol;(S)-N-Bocphenylalaninol;SCHEMBL271855;DTXSID20369969;tert-butyl (S)-(1-hydroxy-3-phenylpropan-2-yl)carbamate;CS-M0537;AC-135;AKOS005259786;DS-1113;Boc-(S)-2-amino-3-phenyl-1-propanol;N-((t-butyloxy)carbonyl)-phenylalaninol;HY-75947;PD196061;N-(tert.-butyloxycarbonyl)-L-phenylalaninol;AM20040982;B2604;tert-Butyl 1-benzyl-2-hydroxyethylcarbamate #;M03448;(S)-2-tert-butoxycarbonylamino-3-phenylpropanol;EN300-6193647;(S)-2-(Boc-amino)-3-phenyl-1-propanol, 98%;tert-butyl (1S)-1-benzyl-2-hydroxyethylcarbamate;(2S)-2-t-Butyloxycarbonylamino-3-phenyl-1-propanol;J-640372;J-640373;J-800378;Q-101622;(S)-2-(tert-Butoxycarbonylamino)-3-phenyl-1-propanol;N-tert-butoxycarbonyl-(S)-1-benzyl-1-aminoethan-2-ol;(2S)-2-(tert-butoxycarbonyl)amino-3-phenyl-1-propanol;(2S)-2-(tert-butoxycarbonylamino)-3-phenyl-1-propanol;(S)-(-)-2-(t-Butoxycarbonylamino)-3-phenyl-1-propanol;F0001-0517;((S)-1-Benzyl-2-hydroxyethyl)carbamic acid t-butyl ester;(S)-(-)-2-(tertbutoxycarbonylamino)-3-phenyl-1-propanol;n-[(1S)-2-hydroxy-1-benzylethyl](tert-butoxy)carboxamide;tert.-butyl-[(2S)-1-hydroxy-3-phenylpropane-2-yl]carbamate;((S)-1-Hydroxymethyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester;(s)-(1-hydroxymethyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester;(S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-phenylmethyl-1-ethanol;Carbamic acid, [(1S)-1-(hydroxymethyl)-2-phenylethyl]-, 1,1-dimethylethyl ester;Carbamic acid, [1-(hydroxymethyl)-2-phenylethyl]-, 1,1-dimethylethyl ester, (s)-

Suppliers and Price of N-Boc-L-phenylalaninol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TCI Chemical
N-(tert-Butoxycarbonyl)-L-phenylalaninol >97.0%(GC)
5g
$ 22.00

SynQuest Laboratories
N-t-Boc-L-Phenylalaninol
25 g
$ 58.00

SynQuest Laboratories
N-t-Boc-L-Phenylalaninol
5 g
$ 18.00

SynQuest Laboratories
N-t-Boc-L-Phenylalaninol
100 g
$ 175.00

Sigma-Aldrich
(S)-2-(Boc-amino)-3-phenyl-1-propanol 98%
10g
$ 198.00

Oakwood
Boc-L-Phenylalaninol 98%
1g
$ 20.00

Matrix Scientific
Boc-L-phenylalaninol 95+%
5g
$ 37.00

Iris Biotech GmbH
Boc-L-Phenylalaninol
25 g
$ 1080.00

Crysdot
Boc-Phenylalaninol 95+%
100g
$ 139.00

ChemScene
(S)-tert-butyl1-hydroxy-3-phenylpropan-2-ylcarbamate 99.94%
100g
$ 99.00

Total 108 raw suppliers

Chemical Property of N-Boc-L-phenylalaninol Edit

Chemical Property:

Appearance/Colour:white to light yellow crystal powder
Melting Point:94-96 °C(lit.)
Refractive Index:1.5280 (estimate)
Boiling Point:410.1 °C at 760 mmHg
PKA:12.07±0.46(Predicted)
Flash Point:201.8 °C
PSA：58.56000
Density:1.085 g/cm³
LogP:2.50560
Storage Temp.:-15°C
Water Solubility.:Insoluble in water.
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:251.15214353
Heavy Atom Count:18
Complexity:254

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(tert-Butoxycarbonyl)-L-phenylalaninol >97.0%(GC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(CC1=CC=CC=C1)CO
Isomeric SMILES:CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)CO
Uses Protected L-Phenylalaninol, an intermediate in the preparation of (R)-Amphetamine. N-Boc-L-phenylalaninol is employed in the synthesis of biochemically active compounds.

Technology Process of N-Boc-L-phenylalaninol

There total 83 articles about N-Boc-L-phenylalaninol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 3182-95-4
L-Phenylalaninol

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

Guidance literature:: In dichloromethane;
DOI:10.1002/1521-3773(20000804)39:15<2752::AID-ANIE2752>3.0.CO;2-5

Reference yield: 100.0%

: 51987-73-6
(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 65 ℃; for 1h;
DOI:10.1039/c6ra14016e

Reference yield: 100.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 66605-57-0
(S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol

Guidance literature:: N-tert-butoxycarbonyl-L-phenylalanine; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -15 ℃; for 0.25h;

With sodium tetrahydroborate; In tetrahydrofuran; water; at -15 ℃; for 1h;
DOI:10.1128/AAC.01152-16