(2-hydroxy-2-phenylethyl)diphenylphosphine oxide

Base Information

• Chemical Name: (2-hydroxy-2-phenylethyl)diphenylphosphine oxide
• CAS No.: 100065-14-3
• Molecular Formula: C₂₀H₁₉O₂P
• Molecular Weight: 322.343
• Mol file: 100065-14-3.mol

Synonyms:(2-hydroxy-2-phenylethyl)diphenylphosphine oxide

Chemical Property of (2-hydroxy-2-phenylethyl)diphenylphosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-hydroxy-2-phenylethyl)diphenylphosphine oxide

There total 14 articles about (2-hydroxy-2-phenylethyl)diphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C26H24NOP (119554-76-6) → (2-hydroxy-2-phenylethyl)diphenylphosphine oxide (100065-14-3)

Guidance literature:

With carbon dioxide; In tetrahydrofuran; at -70 ℃;

DOI:10.1055/s-1988-27641

Reference yield: 87.0%

benzaldehyde (100-52-7) + diphenyl(methyl)phosphine oxide (2129-89-7) → (2-hydroxy-2-phenylethyl)diphenylphosphine oxide (100065-14-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; -78 deg C to r.t.;

Reference yield: 85.0%

(2-(tert-butylperoxy)-2-phenylethyl)diphenylphosphine oxide → (2-hydroxy-2-phenylethyl)diphenylphosphine oxide (100065-14-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 8h;

DOI:10.1002/adsc.201900873

upstream raw materials:

benzaldehyde

diphenyl(methyl)phosphine oxide

C₂₂H₃₃O₄PTi

C₂₆H₂₄ClCrO₂P₂

Downstream raw materials:

(Z)-(2-phenylethenyl)diphenylphosphine oxide

[2-(Diphenyl-phosphinoyl)-1-phenyl-ethoxy]-trimethyl-silane

(1'R)-N-Benzyl-N-(1'-phenylethyl)-2-diphenylphosphinoyl-1-phenylethylamine

(E)-2-diphenylphosphinyl-2-trimethylsilylstyrene

Refernces

• 1、 Li, Meng-Shun,Zhang, Qiang,Hu, Dong-Yan,Zhong, Wen-Wu,Cheng, Ming,Ji, Jian-Xin,Wei, Wei. "Catalyst-free direct difunctionalization of alkenes with H-phosphine oxides and dioxygen: A facile and green approach to β-hydroxyphosphine oxides". . p. 2642 - 2646. Retrieved 2016.
• 2、 Cicco, Luciana,Fombona-Pascual, Alba,Sánchez-Condado, Alba,Carriedo, Gabino A.,Perna, Filippo M.,Capriati, Vito,Presa Soto, Alejandro,García-álvarez, Joaquín. "Fast and Chemoselective Addition of Highly Polarized Lithium Phosphides Generated in Deep Eutectic Solvents to Aldehydes and Epoxides". . p. 4967 - 4973. Retrieved 2020/08/21.
• 3、 -. "INTRODUCTION REACTION OF OH GROUP AND C=O GROUP". Paragraph 0129. . Retrieved 2017/08/02.