N-(2-Bromobenzyloxycarbonyloxy)succinimide

Base Information

• Chemical Name: N-(2-Bromobenzyloxycarbonyloxy)succinimide
• CAS No.: 128611-93-8
• Molecular Formula: C12H10BrNO5
• Molecular Weight: 328.12
• Hs Code.: 29339990
• Mol file: 128611-93-8.mol

Synonyms:2,5-Pyrrolidinedione,1-[[[(2-bromophenyl)methoxy]carbonyl]oxy]- (9CI);2-Br-Z-Osu;Z(2-Br)OSu;2-Bromobenzyl succinimdyl carbonate;N-(2-Bromo-Z)succinimide;

Chemical Property of N-(2-Bromobenzyloxycarbonyloxy)succinimide

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 3.35E-07mmHg at 25°C
• Melting Point: 105-108 °C
• Refractive Index: 1.621
• Boiling Point: 418.2 °C at 760 mmHg
• Flash Point: 206.7 °C
• PSA: 72.91000
• Density: 1.7 g/cm³
• LogP: 2.10420
• Storage Temp.: Store at 0-5°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

2-Bromobenzyl succinimdyl carbonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 43
• Safety Statements: 22-36/37-24/25-36-26-37-24

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-Bromobenzyloxycarbonyloxy)succinimide

There total 1 articles about N-(2-Bromobenzyloxycarbonyloxy)succinimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

di(succinimido) carbonate (74124-79-1) + o-bromobenzyl alcohol (18982-54-2) → (ortho-bromobenzyloxy)carbonyloxysuccinimide (128611-93-8)

Guidance literature:

With dmap; In dichloromethane; acetonitrile; for 6h; Ambient temperature;

DOI:10.1248/cpb.38.110

Reference yield: 70.0%

2-methylisothiourea sulphate (14527-26-5,867-44-7,147895-43-0) + (ortho-bromobenzyloxy)carbonyloxysuccinimide (128611-93-8) → N,N'-bis(ortho-bromobenzyloxycarbonyl)-S-methylisothiourea

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 24h;

DOI:10.1055/s-2003-44374

Reference yield: 56.1%

endo-7-azabicyclo[2.2.1]hept-2-ylamine dihydrochloride + (ortho-bromobenzyloxy)carbonyloxysuccinimide (128611-93-8) → 2-bromobenzyl endo-2-amino-7-azabicyclo[2.2.1]heptane-7-carboxylate

Guidance literature:

With sodium hydrogencarbonate; In methanol; water; at 0 ℃; for 4h;

DOI:10.1016/j.bmcl.2007.10.028

upstream raw materials:

di(succinimido) carbonate

o-bromobenzyl alcohol

Downstream raw materials:

(2S,3aS,7aS)-1-{(R)-4-[6-Amino-2-(2-bromo-benzyloxycarbonylamino)-hexanoylamino]-4-carboxy-butyryl}-octahydro-indole-2-carboxylic acid

Refernces